eprintid: 10150819
rev_number: 12
eprint_status: archive
userid: 699
dir: disk0/10/15/08/19
datestamp: 2022-06-28 10:23:19
lastmod: 2023-06-14 16:49:45
status_changed: 2022-06-28 10:23:19
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Yee, Chee-Seng
creators_name: Gordon, Caroline
creators_name: Akil, Mohammed
creators_name: Lanyon, Peter
creators_name: Edwards, Christopher J
creators_name: Isenberg, David A
creators_name: Rahman, Anisur
creators_name: Teh, Lee-Suan
creators_name: Tosounidou, Sofia
creators_name: Stevens, Robert
creators_name: Prabu, Athiveeraramapandian
creators_name: Griffiths, Bridget
creators_name: McHugh, Neil
creators_name: Bruce, Ian N
creators_name: Ahmad, Yasmeen
creators_name: Khamashta, Munther A
creators_name: Farewell, Vernon T
title: The BILAG-2004 index is associated with development of new damage in SLE
ispublished: pub
divisions: C10
divisions: G90
divisions: B02
divisions: UCL
divisions: D17
keywords: BILAG-2004, Damage, Disease activity, Mortality, SLE
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: OBJECTIVE: To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined. METHODS: This was a multicentre longitudinal study. Patients were recruited within 12 months of achieving 4th ACR classification criterion for SLE. Data were collected on disease activity, damage, SLE-specific drug exposure, cardiovascular risk factors, antiphospholipid syndrome status and death at every visit. This study ran from 1st January 2005 to 31st December 2017. Descriptive statistics were used to analyse mortality and development of new damage. Poisson regression was used to examine potential explanatory variables for development of new damage. RESULTS: 273 SLE patients were recruited with total follow-up of 1767 patient-years (median 73.4 months). There were 6348 assessments with disease activity scores available for analysis. During follow-up, 13 deaths and 114 new damage items (in 83 patients) occurred. The incidence rate for development of damage was higher in the first 3 years before stabilising at a lower rate. Overall rate for damage accrual was 61.1 per 1000 person-years (95% CI : 50.6, 73.8). Analysis showed that active disease scores according to BILAG-2004 index (systems scores of A or B, counts of systems with A and BILAG-2004 numerical score) were associated with development of new damage. Low disease activity (LDA) states (BILAG-2004 LDA and BILAG Systems Tally (BST) persistent LDA) were inversely associated with development of damage. CONCLUSIONS: BILAG-2004 index is associated with new damage. BILAG-2004 LDA and BST persistent LDA can be considered as treatment targets.
date: 2023-02
date_type: published
publisher: Oxford University Press (OUP)
official_url: https://doi.org/10.1093/rheumatology/keac334
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1961808
doi: 10.1093/rheumatology/keac334
medium: Print-Electronic
pii: 6605217
lyricists_name: Rahman, Mohammed
lyricists_id: ARAHM26
actors_name: Rahman, Mohammed
actors_id: ARAHM26
actors_role: owner
full_text_status: public
publication: Rheumatology
volume: 62
number: 2
pagerange: 668-675
event_location: England
citation:        Yee, Chee-Seng;    Gordon, Caroline;    Akil, Mohammed;    Lanyon, Peter;    Edwards, Christopher J;    Isenberg, David A;    Rahman, Anisur;                                         ... Farewell, Vernon T; + view all <#>        Yee, Chee-Seng;  Gordon, Caroline;  Akil, Mohammed;  Lanyon, Peter;  Edwards, Christopher J;  Isenberg, David A;  Rahman, Anisur;  Teh, Lee-Suan;  Tosounidou, Sofia;  Stevens, Robert;  Prabu, Athiveeraramapandian;  Griffiths, Bridget;  McHugh, Neil;  Bruce, Ian N;  Ahmad, Yasmeen;  Khamashta, Munther A;  Farewell, Vernon T;   - view fewer <#>    (2023)    The BILAG-2004 index is associated with development of new damage in SLE.                   Rheumatology , 62  (2)   pp. 668-675.    10.1093/rheumatology/keac334 <https://doi.org/10.1093/rheumatology%2Fkeac334>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10150819/2/Rahman_BILAG-2004%20Predictive%20Validity%20manuscript%20revision%203.2.pdf