TY  - JOUR
VL  - 62
SP  - 668
IS  - 2
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
UR  - https://doi.org/10.1093/rheumatology/keac334
A1  - Yee, Chee-Seng
A1  - Gordon, Caroline
A1  - Akil, Mohammed
A1  - Lanyon, Peter
A1  - Edwards, Christopher J
A1  - Isenberg, David A
A1  - Rahman, Anisur
A1  - Teh, Lee-Suan
A1  - Tosounidou, Sofia
A1  - Stevens, Robert
A1  - Prabu, Athiveeraramapandian
A1  - Griffiths, Bridget
A1  - McHugh, Neil
A1  - Bruce, Ian N
A1  - Ahmad, Yasmeen
A1  - Khamashta, Munther A
A1  - Farewell, Vernon T
JF  - Rheumatology
AV  - public
Y1  - 2023/02//
EP  - 675
TI  - The BILAG-2004 index is associated with development of new damage in SLE
PB  - Oxford University Press (OUP)
N2  - OBJECTIVE: To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined. METHODS: This was a multicentre longitudinal study. Patients were recruited within 12?months of achieving 4th ACR classification criterion for SLE. Data were collected on disease activity, damage, SLE-specific drug exposure, cardiovascular risk factors, antiphospholipid syndrome status and death at every visit. This study ran from 1st January 2005 to 31st December 2017. Descriptive statistics were used to analyse mortality and development of new damage. Poisson regression was used to examine potential explanatory variables for development of new damage. RESULTS: 273 SLE patients were recruited with total follow-up of 1767 patient-years (median 73.4?months). There were 6348 assessments with disease activity scores available for analysis. During follow-up, 13 deaths and 114 new damage items (in 83 patients) occurred. The incidence rate for development of damage was higher in the first 3?years before stabilising at a lower rate. Overall rate for damage accrual was 61.1 per 1000 person-years (95% CI : 50.6, 73.8). Analysis showed that active disease scores according to BILAG-2004 index (systems scores of A or B, counts of systems with A and BILAG-2004 numerical score) were associated with development of new damage. Low disease activity (LDA) states (BILAG-2004 LDA and BILAG Systems Tally (BST) persistent LDA) were inversely associated with development of damage. CONCLUSIONS: BILAG-2004 index is associated with new damage. BILAG-2004 LDA and BST persistent LDA can be considered as treatment targets.
ID  - discovery10150819
KW  - BILAG-2004
KW  -  Damage
KW  -  Disease activity
KW  -  Mortality
KW  -  SLE
ER  -