@article{discovery10150819,
         journal = {Rheumatology},
       publisher = {Oxford University Press (OUP)},
            year = {2023},
           title = {The BILAG-2004 index is associated with development of new damage in SLE},
           month = {February},
          number = {2},
           pages = {668--675},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
          volume = {62},
        keywords = {BILAG-2004, Damage, Disease activity, Mortality, SLE},
        abstract = {OBJECTIVE: To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined. METHODS: This was a multicentre longitudinal study. Patients were recruited within 12 months of achieving 4th ACR classification criterion for SLE. Data were collected on disease activity, damage, SLE-specific drug exposure, cardiovascular risk factors, antiphospholipid syndrome status and death at every visit. This study ran from 1st January 2005 to 31st December 2017. Descriptive statistics were used to analyse mortality and development of new damage. Poisson regression was used to examine potential explanatory variables for development of new damage. RESULTS: 273 SLE patients were recruited with total follow-up of 1767 patient-years (median 73.4 months). There were 6348 assessments with disease activity scores available for analysis. During follow-up, 13 deaths and 114 new damage items (in 83 patients) occurred. The incidence rate for development of damage was higher in the first 3 years before stabilising at a lower rate. Overall rate for damage accrual was 61.1 per 1000 person-years (95\% CI : 50.6, 73.8). Analysis showed that active disease scores according to BILAG-2004 index (systems scores of A or B, counts of systems with A and BILAG-2004 numerical score) were associated with development of new damage. Low disease activity (LDA) states (BILAG-2004 LDA and BILAG Systems Tally (BST) persistent LDA) were inversely associated with development of damage. CONCLUSIONS: BILAG-2004 index is associated with new damage. BILAG-2004 LDA and BST persistent LDA can be considered as treatment targets.},
          author = {Yee, Chee-Seng and Gordon, Caroline and Akil, Mohammed and Lanyon, Peter and Edwards, Christopher J and Isenberg, David A and Rahman, Anisur and Teh, Lee-Suan and Tosounidou, Sofia and Stevens, Robert and Prabu, Athiveeraramapandian and Griffiths, Bridget and McHugh, Neil and Bruce, Ian N and Ahmad, Yasmeen and Khamashta, Munther A and Farewell, Vernon T},
             url = {https://doi.org/10.1093/rheumatology/keac334}
}