eprintid: 10150442
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/15/04/42
datestamp: 2022-06-20 11:21:30
lastmod: 2022-06-20 11:21:30
status_changed: 2022-06-20 11:21:30
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Nyberg, Solja T
creators_name: Batty, G David
creators_name: Pentti, Jaana
creators_name: Madsen, Ida EH
creators_name: Alfredsson, Lars
creators_name: Bjorner, Jakob B
creators_name: Borritz, Marianne
creators_name: Burr, Hermann
creators_name: Ervasti, Jenni
creators_name: Goldberg, Marcel
creators_name: Jokela, Markus
creators_name: Knutsson, Anders
creators_name: Koskinen, Aki
creators_name: Lallukka, Tea
creators_name: Lindbohm, Joni V
creators_name: Nielsen, Martin L
creators_name: Oksanen, Tuula
creators_name: Pejtersen, Jan H
creators_name: Pietiläinen, Olli
creators_name: Rahkonen, Ossi
creators_name: Rugulies, Reiner
creators_name: Shipley, Martin J
creators_name: Sipilä, Pyry N
creators_name: Sørensen, Jeppe K
creators_name: Stenholm, Sari
creators_name: Suominen, Sakari
creators_name: Väänänen, Ari
creators_name: Vahtera, Jussi
creators_name: Virtanen, Marianna
creators_name: Westerlund, Hugo
creators_name: Zins, Marie
creators_name: Singh-Manoux, Archana
creators_name: Kivimäki, Mika
title: Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank
ispublished: pub
divisions: UCL
divisions: G19
divisions: D12
divisions: B02
keywords: Alcohol consumption, Binge drinking, Chronic diseases, Disease-free life-years
note: © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/)
abstract: BACKGROUND: 
Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use.

METHODS: 
In primary analysis, we pooled individual-level data from up to 129,942 adults across 12 cohort studies with baseline data collection on alcohol consumption, drinking patterns, and history between 1986 and 2005 (the IPD-Work Consortium). Self-reported alcohol consumption was categorised according to UK guidelines – non-drinking (never or former drinkers); moderate consumption (1–14 units); heavy consumption (>14 units per week). We further subdivided moderate and heavy drinkers by binge drinking pattern (alcohol-induced loss of consciousness). In addition, we assessed problem drinking using linked data on hospitalisations due to alcohol abuse or poisoning. Follow-up for chronic diseases for all participants included incident type 2 diabetes, coronary heart disease, stroke, cancer, and respiratory disease (asthma and chronic obstructive pulmonary disease) as ascertained via linkage to national morbidity and mortality registries, repeated medical examinations, and/or self-report. We estimated years lived without any of these diseases between 40 and 75 years of age according to sex and characteristics of alcohol use. We repeated the main analyses using data from 427,621 participants in the UK Biobank cohort study.

FINDINGS: 
During 1·73 million person-years at risk, 22,676 participants in IPD-Work cohorts developed at least one chronic condition. From age 40 to 75 years, never-drinkers [men: 29·3 (95%CI 27·9–30·8) years, women 29·8 (29·2–30·4) years)] and moderate drinkers with no binge drinking habit [men 28·7 (28·4–29·0) years, women 29·6 (29·4–29·7) years] had the longest disease-free life span. A much shorter disease-free life span was apparent in participants who experienced alcohol poisoning [men 23·4 (20·9–26·0) years, women 24·0 (21·4–26·5) years] and those with self-reported heavy overall consumption and binge drinking [men: 26·0 (25·3–26·8), women 27·5 (26·4–28·5) years]. The pattern of results for alcohol poisoning and self-reported alcohol consumption was similar in UK Biobank. In IPD-Work and UK Biobank, differences in disease-free years between self-reported moderate drinkers and heavy drinkers were 1·5 years or less.

INTERPRETATION: 
Individuals with alcohol poisonings or heavy self-reported overall consumption combined with a binge drinking habit have a marked 3- to 6-year loss in healthy longevity. Differences in disease-free life between categories of self-reported weekly alcohol consumption were smaller.

FUNDING: 
Medical Research Council, National Institute on Aging, NordForsk, Academy of Finland, Finnish Work Environment Fund.
date: 2022-08
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.lanepe.2022.100417
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1961919
doi: 10.1016/j.lanepe.2022.100417
medium: Electronic-eCollection
pii: S2666-7762(22)00111-9
lyricists_name: Singh-Manoux, Archana
lyricists_name: Shipley, Martin
lyricists_name: Batty, George
lyricists_name: Kivimaki, Mika
lyricists_id: ASING25
lyricists_id: MJSHI88
lyricists_id: GDBAT67
lyricists_id: MJKIV95
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: The Lancet Regional Health Europe
volume: 19
article_number: 100417
event_location: England
citation:        Nyberg, Solja T;    Batty, G David;    Pentti, Jaana;    Madsen, Ida EH;    Alfredsson, Lars;    Bjorner, Jakob B;    Borritz, Marianne;                                                                                                         ... Kivimäki, Mika; + view all <#>        Nyberg, Solja T;  Batty, G David;  Pentti, Jaana;  Madsen, Ida EH;  Alfredsson, Lars;  Bjorner, Jakob B;  Borritz, Marianne;  Burr, Hermann;  Ervasti, Jenni;  Goldberg, Marcel;  Jokela, Markus;  Knutsson, Anders;  Koskinen, Aki;  Lallukka, Tea;  Lindbohm, Joni V;  Nielsen, Martin L;  Oksanen, Tuula;  Pejtersen, Jan H;  Pietiläinen, Olli;  Rahkonen, Ossi;  Rugulies, Reiner;  Shipley, Martin J;  Sipilä, Pyry N;  Sørensen, Jeppe K;  Stenholm, Sari;  Suominen, Sakari;  Väänänen, Ari;  Vahtera, Jussi;  Virtanen, Marianna;  Westerlund, Hugo;  Zins, Marie;  Singh-Manoux, Archana;  Kivimäki, Mika;   - view fewer <#>    (2022)    Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank.                   The Lancet Regional Health Europe , 19     , Article 100417.  10.1016/j.lanepe.2022.100417 <https://doi.org/10.1016/j.lanepe.2022.100417>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10150442/1/1-s2.0-S2666776222001119-main.pdf