eprintid: 10150442 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/15/04/42 datestamp: 2022-06-20 11:21:30 lastmod: 2022-06-20 11:21:30 status_changed: 2022-06-20 11:21:30 type: article metadata_visibility: show sword_depositor: 699 creators_name: Nyberg, Solja T creators_name: Batty, G David creators_name: Pentti, Jaana creators_name: Madsen, Ida EH creators_name: Alfredsson, Lars creators_name: Bjorner, Jakob B creators_name: Borritz, Marianne creators_name: Burr, Hermann creators_name: Ervasti, Jenni creators_name: Goldberg, Marcel creators_name: Jokela, Markus creators_name: Knutsson, Anders creators_name: Koskinen, Aki creators_name: Lallukka, Tea creators_name: Lindbohm, Joni V creators_name: Nielsen, Martin L creators_name: Oksanen, Tuula creators_name: Pejtersen, Jan H creators_name: Pietiläinen, Olli creators_name: Rahkonen, Ossi creators_name: Rugulies, Reiner creators_name: Shipley, Martin J creators_name: Sipilä, Pyry N creators_name: Sørensen, Jeppe K creators_name: Stenholm, Sari creators_name: Suominen, Sakari creators_name: Väänänen, Ari creators_name: Vahtera, Jussi creators_name: Virtanen, Marianna creators_name: Westerlund, Hugo creators_name: Zins, Marie creators_name: Singh-Manoux, Archana creators_name: Kivimäki, Mika title: Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank ispublished: pub divisions: UCL divisions: G19 divisions: D12 divisions: B02 keywords: Alcohol consumption, Binge drinking, Chronic diseases, Disease-free life-years note: © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) abstract: BACKGROUND: Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use. METHODS: In primary analysis, we pooled individual-level data from up to 129,942 adults across 12 cohort studies with baseline data collection on alcohol consumption, drinking patterns, and history between 1986 and 2005 (the IPD-Work Consortium). Self-reported alcohol consumption was categorised according to UK guidelines – non-drinking (never or former drinkers); moderate consumption (1–14 units); heavy consumption (>14 units per week). We further subdivided moderate and heavy drinkers by binge drinking pattern (alcohol-induced loss of consciousness). In addition, we assessed problem drinking using linked data on hospitalisations due to alcohol abuse or poisoning. Follow-up for chronic diseases for all participants included incident type 2 diabetes, coronary heart disease, stroke, cancer, and respiratory disease (asthma and chronic obstructive pulmonary disease) as ascertained via linkage to national morbidity and mortality registries, repeated medical examinations, and/or self-report. We estimated years lived without any of these diseases between 40 and 75 years of age according to sex and characteristics of alcohol use. We repeated the main analyses using data from 427,621 participants in the UK Biobank cohort study. FINDINGS: During 1·73 million person-years at risk, 22,676 participants in IPD-Work cohorts developed at least one chronic condition. From age 40 to 75 years, never-drinkers [men: 29·3 (95%CI 27·9–30·8) years, women 29·8 (29·2–30·4) years)] and moderate drinkers with no binge drinking habit [men 28·7 (28·4–29·0) years, women 29·6 (29·4–29·7) years] had the longest disease-free life span. A much shorter disease-free life span was apparent in participants who experienced alcohol poisoning [men 23·4 (20·9–26·0) years, women 24·0 (21·4–26·5) years] and those with self-reported heavy overall consumption and binge drinking [men: 26·0 (25·3–26·8), women 27·5 (26·4–28·5) years]. The pattern of results for alcohol poisoning and self-reported alcohol consumption was similar in UK Biobank. In IPD-Work and UK Biobank, differences in disease-free years between self-reported moderate drinkers and heavy drinkers were 1·5 years or less. INTERPRETATION: Individuals with alcohol poisonings or heavy self-reported overall consumption combined with a binge drinking habit have a marked 3- to 6-year loss in healthy longevity. Differences in disease-free life between categories of self-reported weekly alcohol consumption were smaller. FUNDING: Medical Research Council, National Institute on Aging, NordForsk, Academy of Finland, Finnish Work Environment Fund. date: 2022-08 date_type: published publisher: Elsevier BV official_url: https://doi.org/10.1016/j.lanepe.2022.100417 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1961919 doi: 10.1016/j.lanepe.2022.100417 medium: Electronic-eCollection pii: S2666-7762(22)00111-9 lyricists_name: Singh-Manoux, Archana lyricists_name: Shipley, Martin lyricists_name: Batty, George lyricists_name: Kivimaki, Mika lyricists_id: ASING25 lyricists_id: MJSHI88 lyricists_id: GDBAT67 lyricists_id: MJKIV95 actors_name: Bracey, Alan actors_id: ABBRA90 actors_role: owner full_text_status: public publication: The Lancet Regional Health Europe volume: 19 article_number: 100417 event_location: England citation: Nyberg, Solja T; Batty, G David; Pentti, Jaana; Madsen, Ida EH; Alfredsson, Lars; Bjorner, Jakob B; Borritz, Marianne; ... Kivimäki, Mika; + view all <#> Nyberg, Solja T; Batty, G David; Pentti, Jaana; Madsen, Ida EH; Alfredsson, Lars; Bjorner, Jakob B; Borritz, Marianne; Burr, Hermann; Ervasti, Jenni; Goldberg, Marcel; Jokela, Markus; Knutsson, Anders; Koskinen, Aki; Lallukka, Tea; Lindbohm, Joni V; Nielsen, Martin L; Oksanen, Tuula; Pejtersen, Jan H; Pietiläinen, Olli; Rahkonen, Ossi; Rugulies, Reiner; Shipley, Martin J; Sipilä, Pyry N; Sørensen, Jeppe K; Stenholm, Sari; Suominen, Sakari; Väänänen, Ari; Vahtera, Jussi; Virtanen, Marianna; Westerlund, Hugo; Zins, Marie; Singh-Manoux, Archana; Kivimäki, Mika; - view fewer <#> (2022) Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank. The Lancet Regional Health Europe , 19 , Article 100417. 10.1016/j.lanepe.2022.100417 <https://doi.org/10.1016/j.lanepe.2022.100417>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10150442/1/1-s2.0-S2666776222001119-main.pdf