TY  - JOUR
IS  - 1119
KW  - Adult
KW  -  Aged
KW  -  Aged
KW  -  80 and over
KW  -  Breast
KW  -  Breast Neoplasms
KW  -  Diffusion Magnetic Resonance Imaging
KW  -  Echo-Planar Imaging
KW  -  Female
KW  -  Humans
KW  -  Middle Aged
KW  -  Reproducibility of Results
KW  -  Sensitivity and Specificity
A1  - Baxter, Gabrielle C
A1  - Patterson, Andrew J
A1  - Woitek, Ramona
A1  - Allajbeu, Iris
A1  - Graves, Martin J
A1  - Gilbert, Fiona
AV  - public
ID  - discovery10149891
VL  - 94
JF  - British Journal of Radiology
N1  - © 2021 The Authors. Published by the British Institute of Radiology
under the terms of the Creative Commons Attribution-NonCommercial
4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/,
which permits unrestricted non-commercial reuse, provided the original
author and source are credited.
TI  - Improving the image quality of DWI in breast cancer: comparison of multi-shot DWI using multiplexed sensitivity encoding to conventional single-shot echo-planar imaging DWI
N2  - OBJECTIVE: To compare diffusion-weighted images (DWI) acquired using single-shot echo-planar imaging (ss-EPI) and multiplexed sensitivity encoding (MUSE) in breast cancer. METHODS: 20 females with pathologically confirmed breast cancer (age 51 ± 12 years) were imaged with ss-EPI-DWI and MUSE-DWI. ADC, normalised ADC (nADC), blur and distortion metrics and qualitative image quality scores were compared. The Crété-Roffet and Mattes mutual information metrics were used to evaluate blurring and distortion, respectively. In a breast phantom, six permutations of MUSE-DWI with varying parallel acceleration factor and number of shots were compared. Differences in ADC and nADC were compared using the coefficient of variation in the phantom and a paired t-test in patients. Differences in blur, distortion and qualitative metrics were analysed using a Wilcoxon signed-rank test. RESULTS: There was a low coefficient of variation (<2%) in ADC between ss-EPI-DWI and all MUSE-DWI permutations acquired using the phantom. 22 malignant and three benign lesions were identified in 20 patients. ADC values measured using MUSE were significantly lower compared to ss-EPI for malignant but not benign lesions (p < 0.001, p = 0.21). nADC values were not significantly different (p = 0.62, p = 0.28). Blurring and distortion improved with number of shots and acceleration factor, and significantly improved with MUSE in patients (p < 0.001, p = 0.002). Qualitatively, image quality improved using MUSE. CONCLUSION: MUSE improves the image quality of breast DWI compared to ss-EPI. ADVANCES IN KNOWLEDGE: MUSE-DWI has superior image quality and reduced blurring and distortion compared to ss-EPI-DWI in breast cancer.
PB  - British Institute of Radiology
UR  - https://doi.org/10.1259/bjr.20200427
Y1  - 2021/03//
ER  -