TY  - JOUR
TI  - Quantitative MRI Harmonization to Maximize Clinical Impact: The RIN-Neuroimaging Network
JF  - Frontiers in Neurology
N1  - t © 2022 Nigri, Ferraro, Gandini Wheeler-Kingshott, Tosetti, Redolfi,
Forloni, D?Angelo, Aquino, Biagi, Bosco, Carne, De Francesco, Demichelis, Gianeri,
Lagana, Micotti, Napolitano, Palesi, Pirastru, Savini, Alberici, Amato, Arrigoni,
Baglio, Bozzali, Castellano, Cavaliere, Contarino, Ferrazzi, Gaudino, Marino,
Manzo, Pavone, Politi, Roccatagliata, Rognone, Rossi, Tonon, Lodi, Tagliavini,
Bruzzone and The RIN?Neuroimaging. This is an open-access article distributed
under the terms of the Creative Commons Attribution License (CC BY). The use,
distribution or reproduction in other forums is permitted, provided the original
author(s) and the copyright owner(s) are credited and that the original publication
in this journal is cited, in accordance with accepted academic practice. No use,
distribution or reproduction is permitted which does not comply with these terms.
UR  - https://doi.org/10.3389/fneur.2022.855125
Y1  - 2022/04/14/
N2  - Neuroimaging studies often lack reproducibility, one of the cardinal features of the scientific method. Multisite collaboration initiatives increase sample size and limit methodological flexibility, therefore providing the foundation for increased statistical power and generalizable results. However, multisite collaborative initiatives are inherently limited by hardware, software, and pulse and sequence design heterogeneities of both clinical and preclinical MRI scanners and the lack of benchmark for acquisition protocols, data analysis, and data sharing. We present the overarching vision that yielded to the constitution of RIN-Neuroimaging Network, a national consortium dedicated to identifying disease and subject-specific in-vivo neuroimaging biomarkers of diverse neurological and neuropsychiatric conditions. This ambitious goal needs efforts toward increasing the diagnostic and prognostic power of advanced MRI data. To this aim, 23 Italian Scientific Institutes of Hospitalization and Care (IRCCS), with technological and clinical specialization in the neurological and neuroimaging field, have gathered together. Each IRCCS is equipped with high- or ultra-high field MRI scanners (i.e., ?3T) for clinical or preclinical research or has established expertise in MRI data analysis and infrastructure. The actions of this Network were defined across several work packages (WP). A clinical work package (WP1) defined the guidelines for a minimum standard clinical qualitative MRI assessment for the main neurological diseases. Two neuroimaging technical work packages (WP2 and WP3, for clinical and preclinical scanners) established Standard Operative Procedures for quality controls on phantoms as well as advanced harmonized quantitative MRI protocols for studying the brain of healthy human participants and wild type mice. Under FAIR principles, a web-based e-infrastructure to store and share data across sites was also implemented (WP4). Finally, the RIN translated all these efforts into a large-scale multimodal data collection in patients and animal models with dementia (i.e., case study). The RIN-Neuroimaging Network can maximize the impact of public investments in research and clinical practice acquiring data across institutes and pathologies with high-quality and highly-consistent acquisition protocols, optimizing the analysis pipeline and data sharing procedures.
PB  - FRONTIERS MEDIA SA
A1  - Nigri, Anna
A1  - Ferraro, Stefania
A1  - Wheeler-Kingshott, Claudia AM Gandini
A1  - Tosetti, Michela
A1  - Redolfi, Alberto
A1  - Forloni, Gianluigi
A1  - D'Angelo, Egidio
A1  - Aquino, Domenico
A1  - Biagi, Laura
A1  - Bosco, Paolo
A1  - Carne, Irene
A1  - De Francesco, Silvia
A1  - Demichelis, Greta
A1  - Gianeri, Ruben
A1  - Lagana, Maria Marcella
A1  - Micotti, Edoardo
A1  - Napolitano, Antonio
A1  - Palesi, Fulvia
A1  - Pirastru, Alice
A1  - Savini, Giovanni
A1  - Alberici, Elisa
A1  - Amato, Carmelo
A1  - Arrigoni, Filippo
A1  - Baglio, Francesca
A1  - Bozzali, Marco
A1  - Castellano, Antonella
A1  - Cavaliere, Carlo
A1  - Contarino, Valeria Elisa
A1  - Ferrazzi, Giulio
A1  - Gaudino, Simona
A1  - Marino, Silvia
A1  - Manzo, Vittorio
A1  - Pavone, Luigi
A1  - Politi, Letterio S
A1  - Roccatagliata, Luca
A1  - Rognone, Elisa
A1  - Rossi, Andrea
A1  - Tonon, Caterina
A1  - Lodi, Raffaele
A1  - Tagliavini, Fabrizio
A1  - Bruzzone, Maria Grazia
EP  - 12
SN  - 1664-2295
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Clinical Neurology
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  harmonization
KW  -  multisite
KW  -  quantitative MRI
KW  -  QSM
KW  -  diffusion MRI
KW  -  fMRI
KW  -  neuroimaging
KW  -  BIOMARKER DISCOVERY
KW  -  REPRODUCIBILITY
KW  -  PHANTOM
KW  -  STANDARDS
KW  -  DISEASES
KW  -  BURDEN
KW  -  BRAIN
ID  - discovery10149802
VL  - 13
AV  - public
ER  -