eprintid: 10149215
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/14/92/15
datestamp: 2022-05-25 11:51:58
lastmod: 2023-05-11 06:10:10
status_changed: 2022-05-25 11:51:58
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Singla, Pankaj
creators_name: Garg, Saweta
creators_name: Kaur, Sarbjeet
creators_name: Kaur, Navreet
creators_name: Kaur, Navalpreet
creators_name: Aswal, Vinod K
creators_name: Velliou, Eirini
creators_name: Kaur, Harpreet
creators_name: Peeters, Marloes
creators_name: Kumar Mahajan, Rakesh
title: Unusual solubilization capacity of hydrophobic drug olanzapine in polysorbate micelles for improved sustained drug release
ispublished: pub
divisions: C10
divisions: G88
divisions: B02
divisions: UCL
divisions: D16
keywords: Olanzapine, Hydrophobic drug, Loading capacity, Polysorbates, Oral delivery, Small angle neutron scattering
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Polysorbates and Pluronic polymers are straightforward to use to improve the performance of hydrophobic molecules, however, colloidal systems of these polymers are not fully understood and loading of drug molecules in these Polysorbate micelles rely on a plethora of factors. Thus, it is a laborious task to select the optimal Polysorbate as a drug delivery vehicle. To pave the way for use of Polysorbates, three Polysorbates with different hydrophobicity were selected for oral delivery of the hydrophobic drug Olanzapine (OLZ). At higher concentration, Polysorbate T20 with low hydrophobicity accommodated a higher amount of OLZ than other Polysorbates T40 and T60 with higher hydrophobicity. The effect of mixed micelles of Pluronic P84 and Polysorbate (T20, T40, T60) on solubilization of OLZ was also studied at different concentration ratios and the higher OLZ solubilization was found to be in T20:P84 mixed micelles at 3:2 %w/v concentration ratio. Stronger interactions between OLZ and T20 were noticed with isothermal titration calorimetry (ITC), resulting in the higher OLZ solubilization in these micelles. Dynamic light scattering (DLS) and small angle neutron scattering (SANS) measurements revealed that mixed micelles of Polysorbates are greater in sizes than pure polysorbate micelles and the size decreased after loading of OLZ. Furthermore, SANS measurements suggested that decrease in the aggregation number after OLZ loading promoted the loading capacity of the Polysorbate micelle. Polysorbates micelles exhibited the sustained release behavior in biological relevant media, examined with in vitro dialysis release method. Therefore, it is believed that the finding of this work could be useful in the oral delivery formulations in which Polysorbates and Pluronics are primarily used.
date: 2022-08
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.molliq.2022.119256
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1958199
doi: 10.1016/j.molliq.2022.119256
lyricists_name: Velliou, Eirini
lyricists_id: EVELL97
actors_name: Velliou, Eirini
actors_name: Allington-Smith, Dominic
actors_id: EVELL97
actors_id: DAALL44
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Journal of Molecular Liquids
volume: 359
article_number: 119256
citation:        Singla, Pankaj;    Garg, Saweta;    Kaur, Sarbjeet;    Kaur, Navreet;    Kaur, Navalpreet;    Aswal, Vinod K;    Velliou, Eirini;             ... Kumar Mahajan, Rakesh; + view all <#>        Singla, Pankaj;  Garg, Saweta;  Kaur, Sarbjeet;  Kaur, Navreet;  Kaur, Navalpreet;  Aswal, Vinod K;  Velliou, Eirini;  Kaur, Harpreet;  Peeters, Marloes;  Kumar Mahajan, Rakesh;   - view fewer <#>    (2022)    Unusual solubilization capacity of hydrophobic drug olanzapine in polysorbate micelles for improved sustained drug release.                   Journal of Molecular Liquids , 359     , Article 119256.  10.1016/j.molliq.2022.119256 <https://doi.org/10.1016/j.molliq.2022.119256>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10149215/1/Velliou_Revised%20Manuscript%20unmarked10.pdf