TY  - JOUR
Y1  - 2022/04/29/
TI  - Autism spectrum disorders as a risk factor for adolescent self-harm: a retrospective cohort study of 113,286 young people in the UK
PB  - BMC
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third-party material in this article are included in the Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
IS  - 1
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Medicine
KW  -  General & Internal
KW  -  General & Internal Medicine
KW  -  Child and adolescent mental health
KW  -  Epidemiology
KW  -  Autism spectrum disorders
KW  -  Education
KW  -  Data linkage
KW  -  EMERGENCY-DEPARTMENT
KW  -  PSYCHIATRIC-DISORDERS
KW  -  SUICIDE IDEATION
KW  -  MENTAL-HEALTH
KW  -  CHILDREN
KW  -  PREVALENCE
KW  -  ADULTS
KW  -  YOUTH
KW  -  PRESENTATIONS
KW  -  MORTALITY
ID  - discovery10149188
N2  - Background: Individuals with autism spectrum disorder (ASD) are at particularly high risk of suicide and suicide attempts. Presentation to a hospital with self-harm is one of the strongest risk factors for later suicide. We describe the use of a novel data linkage between routinely collected education data and child and adolescent mental health data to examine whether adolescents with ASD are at higher risk than the general population of presenting to emergency care with self-harm. Methods: A retrospective cohort study was conducted on the population aged 11?17 resident in four South London boroughs between January 2009 and March 2013, attending state secondary schools, identified in the National Pupil Database (NPD). Exposure data on ASD status were derived from the NPD. We used Cox regression to model time to first self-harm presentation to the Emergency Department (ED). Results: One thousand twenty adolescents presented to the ED with self-harm, and 763 matched to the NPD. The sample for analysis included 113,286 adolescents (2.2% with ASD). For boys only, there was an increased risk of self-harm associated with ASD (adjusted hazard ratio 2·79, 95% CI 1·40?5·57, P<0·01). Several other factors including school absence, exclusion from school and having been in foster care were also associated with a higher risk of self-harm. Conclusions: This study provides evidence that ASD in boys, and other educational, social and clinical factors, are risk factors for emergency presentation with self-harm in adolescents. These findings are an important step in developing early recognition and prevention programmes.
AV  - public
JF  - BMC Medicine
EP  - 14
A1  - Widnall, Emily
A1  - Epstein, Sophie
A1  - Polling, Catherine
A1  - Velupillai, Sumithra
A1  - Jewell, Amelia
A1  - Dutta, Rina
A1  - Simonoff, Emily
A1  - Stewart, Robert
A1  - Gilbert, Ruth
A1  - Ford, Tamsin
A1  - Hotopf, Matthew
A1  - Hayes, Richard D
A1  - Downs, Johnny
UR  - https://doi.org/10.1186/s12916-022-02329-w
VL  - 20
ER  -