TY  - JOUR
UR  - https://doi.org/10.1161/JAHA.121.025109
TI  - Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis
KW  - MRI
KW  -  hippocampus
KW  -  sensorimotor impairment
KW  -  stroke
N2  - Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results Cross-sectional T1-weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta-Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA-UE (Fugl-Meyer Assessment of Upper Extremity). Robust mixed-effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; ?=0.16) but not contralesional (P=0.96; ?=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; ?=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; ?=-0.26) and contralesional (P=0.006; ?=-0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; ?=-0.21) and extent of sensorimotor damage (P=0.003; ?=-0.15). Conclusions The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.
IS  - 10
PB  - Ovid Technologies (Wolters Kluwer Health)
VL  - 11
A1  - Zavaliangos-Petropulu, Artemis
A1  - Lo, Bethany
A1  - Donnelly, Miranda R
A1  - Schweighofer, Nicolas
A1  - Lohse, Keith
A1  - Jahanshad, Neda
A1  - Barisano, Giuseppe
A1  - Banaj, Nerisa
A1  - Borich, Michael R
A1  - Boyd, Lara A
A1  - Buetefisch, Cathrin M
A1  - Byblow, Winston D
A1  - Cassidy, Jessica M
A1  - Charalambous, Charalambos C
A1  - Conforto, Adriana B
A1  - DiCarlo, Julie A
A1  - Dula, Adrienne N
A1  - Egorova-Brumley, Natalia
A1  - Etherton, Mark R
A1  - Feng, Wuwei
A1  - Fercho, Kelene A
A1  - Geranmayeh, Fatemeh
A1  - Hanlon, Colleen A
A1  - Hayward, Kathryn S
A1  - Hordacre, Brenton
A1  - Kautz, Steven A
A1  - Khlif, Mohamed Salah
A1  - Kim, Hosung
A1  - Kuceyeski, Amy
A1  - Lin, David J
A1  - Liu, Jingchun
A1  - Lotze, Martin
A1  - MacIntosh, Bradley J
A1  - Margetis, John L
A1  - Mohamed, Feroze B
A1  - Piras, Fabrizio
A1  - Ramos-Murguialday, Ander
A1  - Revill, Kate P
A1  - Roberts, Pamela S
A1  - Robertson, Andrew D
A1  - Schambra, Heidi M
A1  - Seo, Na Jin
A1  - Shiroishi, Mark S
A1  - Stinear, Cathy M
A1  - Soekadar, Surjo R
A1  - Spalletta, Gianfranco
A1  - Taga, Myriam
A1  - Tang, Wai Kwong
A1  - Thielman, Gregory T
A1  - Vecchio, Daniela
A1  - Ward, Nick S
A1  - Westlye, Lars T
A1  - Werden, Emilio
A1  - Winstein, Carolee
A1  - Wittenberg, George F
A1  - Wolf, Steven L
A1  - Wong, Kristin A
A1  - Yu, Chunshui
A1  - Brodtmann, Amy
A1  - Cramer, Steven C
A1  - Thompson, Paul M
A1  - Liew, Sook-Lei
Y1  - 2022/05/17/
ID  - discovery10149103
N1  - © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License.
JF  - Journal of the American Heart Association
AV  - public
ER  -