eprintid: 10147804
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/14/78/04
datestamp: 2022-05-04 17:07:11
lastmod: 2022-05-04 17:07:20
status_changed: 2022-05-04 17:07:11
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Hailes, Helen
creators_name: Carter, Eve
creators_name: Ambrose-Dempster, Esther
creators_name: Ward, John M
creators_name: Sheppard, Tom
title: Mechanoenzymatic reactions with whole cell transaminases: shaken, not stirred
ispublished: inpress
divisions: C06
divisions: F56
divisions: B04
divisions: UCL
note: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
abstract: Mechanochemical reactions have emerged in recent years as a green synthetic method because reactions can be performed more rapidly and using less solvent than traditional synthetic approaches. To date, very few mechanoenzymatic reactions have been described. For the first time, transaminases, which are widely used for the amination of aldehydes and ketones, have been used here under mechanoenzymatic conditions to produce amines using significantly less aqueous medium than conventional biocatalytic reactions. The direct use of whole cells was also possible and shorter reaction times could be used to provide amines efficiently with high yields and stereoselectivities.
date: 2022-04-11
date_type: published
publisher: Royal Society of Chemistry (RSC)
official_url: https://doi.org/10.1039/d2gc01006b
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1952435
doi: 10.1039/d2gc01006b
lyricists_name: Sheppard, Thomas
lyricists_id: TSHEP42
actors_name: Barczynska, Patrycja
actors_id: PBARC91
actors_role: owner
full_text_status: public
publication: Green Chemistry
citation:        Hailes, Helen;    Carter, Eve;    Ambrose-Dempster, Esther;    Ward, John M;    Sheppard, Tom;      (2022)    Mechanoenzymatic reactions with whole cell transaminases: shaken, not stirred.                   Green Chemistry        10.1039/d2gc01006b <https://doi.org/10.1039/d2gc01006b>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10147804/1/Sheppard_d2gc01006b.pdf