TY  - JOUR
ID  - discovery10147669
UR  - https://doi.org/10.12703/r-01-000006
Y1  - 2022/03/08/
TI  - Proteolytic regulation of calcium channels - avoiding controversy
N1  - This is the published version of record. For information on re-use, please refer to the publisher?s terms and conditions.
JF  - Faculty Opinions
VL  - 11
PB  - Faculty Opinions Ltd
A1  - Alberts, Bruce
A1  - Colbran, Roger J
A1  - Dolphin, Annette C
A1  - Pitt, Geoffrey S
A1  - Südhof, Thomas C
SN  - 2732-432X
KW  - C-terminal
KW  -  Calcium
KW  -  Calcium channels
KW  -  Cav1.2
N2  - The publication of papers containing data obtained with suboptimal rigor in the experimental design and choice of key reagents, such as antibodies, can result in a lack of reproducibility and generate controversy that can both needlessly divert resources and, in some cases, damage public perception of the scientific enterprise. This exemplary paper by Buonarati et al. (2018)1 shows how a previously published, potentially important paper on calcium channel regulation falls short of the necessary mark, and aims to resolve the resulting controversy.
AV  - public
ER  -