eprintid: 10147408
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/14/74/08
datestamp: 2022-04-27 08:58:44
lastmod: 2022-04-27 08:58:44
status_changed: 2022-04-27 08:58:44
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Azharuddin, Mohammad
creators_name: Zhu, Geyunjian Harry
creators_name: Sengupta, Anirban
creators_name: Hinkula, Jorma
creators_name: Slater, Nigel KH
creators_name: Patra, Hirak K
title: Nano toolbox in immune modulation and nanovaccines.
ispublished: inpress
divisions: C10
divisions: G85
divisions: B02
divisions: UCL
divisions: D16
keywords: immune modulation, immune response, nano toolbox, nanovaccine, vaccine
note: © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
abstract: Despite the great success of vaccines over two centuries, the conventional strategy is based on attenuated/altered microorganisms. However, this is not effective for all microbes and often fails to elicit a protective immune response, and sometimes poses unexpected safety risks. The expanding nano toolbox may overcome some of the roadblocks in vaccine development given the plethora of unique nanoparticle (NP)-based platforms that can successfully induce specific immune responses leading to exciting and novel solutions. Nanovaccines necessitate a thorough understanding of the immunostimulatory effect of these nanotools. We present a comprehensive description of strategies in which nanotools have been used to elicit an immune response and provide a perspective on how nanotechnology can lead to future personalized nanovaccines.
date: 2022-04-19
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.tibtech.2022.03.011
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1950440
doi: 10.1016/j.tibtech.2022.03.011
medium: Print-Electronic
pii: S0167-7799(22)00079-8
lyricists_name: Patra, Hirak
lyricists_id: HPATB22
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: Trends in Biotechnology
event_location: England
citation:        Azharuddin, Mohammad;    Zhu, Geyunjian Harry;    Sengupta, Anirban;    Hinkula, Jorma;    Slater, Nigel KH;    Patra, Hirak K;      (2022)    Nano toolbox in immune modulation and nanovaccines.                   Trends in Biotechnology        10.1016/j.tibtech.2022.03.011 <https://doi.org/10.1016/j.tibtech.2022.03.011>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10147408/1/Patra_Nano%20toolbox%20in%20immune%20modulation%20and%20nanovaccines_AOP.pdf