eprintid: 10147406
rev_number: 10
eprint_status: archive
userid: 699
dir: disk0/10/14/74/06
datestamp: 2022-04-27 15:43:53
lastmod: 2023-01-07 07:10:37
status_changed: 2022-04-27 15:43:53
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Brosseron, Frederic
creators_name: Maass, Anne
creators_name: Kleineidam, Luca
creators_name: Ravichandran, Kishore Aravind
creators_name: Gonzalez, Pablo Garcia
creators_name: McManus, Roisin M
creators_name: Ising, Christina
creators_name: Santarelli, Francesco
creators_name: Kolbe, Carl-Christian
creators_name: Haesler, Lisa M
creators_name: Wolfsgruber, Steffen
creators_name: Marquie, Marta
creators_name: Boada, Merce
creators_name: Orellana, Adelina
creators_name: de Rojas, Itziar
creators_name: Roeske, Sandra
creators_name: Peters, Oliver
creators_name: Cosma, Nicoleta-Carmen
creators_name: Cetindag, Arda
creators_name: Wang, Xiao
creators_name: Priller, Josef
creators_name: Spruth, Eike J
creators_name: Altenstein, Slawek
creators_name: Schneider, Anja
creators_name: Fliessbach, Klaus
creators_name: Wiltfang, Jens
creators_name: Schott, Bjorn H
creators_name: Buerger, Katharina
creators_name: Janowitz, Daniel
creators_name: Dichgans, Martin
creators_name: Perneczky, Robert
creators_name: Rauchmann, Boris-Stephan
creators_name: Teipel, Stefan
creators_name: Kilimann, Ingo
creators_name: Goerss, Doreen
creators_name: Laske, Christoph
creators_name: Munk, Matthias H
creators_name: Duzel, Emrah
creators_name: Yakupov, Renat
creators_name: Dobisch, Laura
creators_name: Metzger, Coraline D
creators_name: Glanz, Wenzel
creators_name: Ewers, Michael
creators_name: Dechent, Peter
creators_name: Haynes, John Dylan
creators_name: Scheffler, Klaus
creators_name: Roy, Nina
creators_name: Rostamzadeh, Ayda
creators_name: Teunissen, Charlotte E
creators_name: Marchant, Natalie L
creators_name: Spottke, Annika
creators_name: Jucker, Mathias
creators_name: Latz, Eicke
creators_name: Wagner, Michael
creators_name: Mengel, David
creators_name: Synofzik, Matthis
creators_name: Jessen, Frank
creators_name: Ramirez, Alfredo
creators_name: Ruiz, Agustin
creators_name: Heneka, Michael T
title: Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease
ispublished: pub
divisions: C07
divisions: D79
divisions: B02
divisions: UCL
divisions: F69
divisions: D05
keywords: Alzheimer's disease; neuroinflammation; biomarker; TAM receptor
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: There is an urgent need to improve the understanding of neuroinflammation in Alzheimer's disease (AD). We analyzed cerebrospinal fluid inflammatory biomarker correlations to brain structural volume and longitudinal cognitive outcomes in the DELCODE study and in a validation cohort of the F.ACE Alzheimer Center Barcelona. We investigated whether respective biomarker changes are evident before onset of cognitive impairment. YKL-40; sTREM2; sAXL; sTyro3; MIF; complement factors C1q, C4, and H; ferritin; and ApoE protein were elevated in pre-dementia subjects with pathological levels of tau or other neurodegeneration markers, demonstrating tight interactions between inflammation and accumulating neurodegeneration even before onset of symptoms. Intriguingly, higher levels of ApoE and soluble TAM receptors sAXL and sTyro3 were related to larger brain structure and stable cognitive outcome at follow-up. Our findings indicate a protective mechanism relevant for intervention strategies aiming to regulate neuroinflammation in subjects with no or subjective symptoms but underlying AD pathology profile.
date: 2022-03-16
date_type: published
publisher: CELL PRESS
official_url: https://doi.org/10.1016/j.neuron.2021.12.016
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1913973
doi: 10.1016/j.neuron.2021.12.016
medium: Print-Electronic
pii: S0896-6273(21)01033-3
lyricists_name: Marchant, Natalie
lyricists_name: Duzel, Emrah
lyricists_id: NLMAR24
lyricists_id: EDUZE48
actors_name: Marchant, Natalie
actors_id: NLMAR24
actors_role: owner
funding_acknowledgements: [German Center for Neurodegenerative Diseases (DZNE e.V.) within the Helmholtz Association]; 01ED2007B [PREADAPT project within the EU Joint Programs for Neurodegenerative Diseases Research (JPND) PERSOMED]; 01ED1619A [PREADAPT project within the JPND PERSOMED (German Federal Ministry of Education and Research [BMBF] grant]; MR/T046171/1 [Medical Research Council within the JPND PERSOMED (PREADAPT project)]; FI20/00215 [Instituto de Salud Carlos III (ISCIII)]; [Grifols SA]; [Fundacion bancaria La Caixa]; [Fundacia ACE]; [CIBERNED]; 115975 [European Union/EFPIA Innovative Medicines Initiative joint undertaking ADAPTED project]; 115985 [European Union/EFPIA Innovative Medicines Initiative joint undertaking MOPEAD project]; [ISCIII-Subdireccion General de Evaluacion]; [Fondo Europeo de Desarrollo Regional (FEDER-`Una manera de hacer Europa')]; [JPco-fuND2 "Multinational research projects on Personalised Medicine for Neurodegenerative Diseases'']; AC19/00097 [PREADAPT project (ISCIII grant)]; AC17/00100 [EURONANOMED III Joint Transnational call]; [JPND grant "GENFI-prox'' (by DLR/BMBF)]; [European Union]; [State of Saxony-Anhalt (Research Alliance "Autonomy in Old Age'')]; PI13/02434 []; PI16/01861 []; PI17/01474 []; PI19/01240 []; PI19/01301 []
full_text_status: public
publication: Neuron
volume: 110
number: 6
pagerange: 1009-1022
pages: 19
event_location: United States
issn: 0896-6273
citation:        Brosseron, Frederic;    Maass, Anne;    Kleineidam, Luca;    Ravichandran, Kishore Aravind;    Gonzalez, Pablo Garcia;    McManus, Roisin M;    Ising, Christina;                                                                                                                                                                                                                     ... Heneka, Michael T; + view all <#>        Brosseron, Frederic;  Maass, Anne;  Kleineidam, Luca;  Ravichandran, Kishore Aravind;  Gonzalez, Pablo Garcia;  McManus, Roisin M;  Ising, Christina;  Santarelli, Francesco;  Kolbe, Carl-Christian;  Haesler, Lisa M;  Wolfsgruber, Steffen;  Marquie, Marta;  Boada, Merce;  Orellana, Adelina;  de Rojas, Itziar;  Roeske, Sandra;  Peters, Oliver;  Cosma, Nicoleta-Carmen;  Cetindag, Arda;  Wang, Xiao;  Priller, Josef;  Spruth, Eike J;  Altenstein, Slawek;  Schneider, Anja;  Fliessbach, Klaus;  Wiltfang, Jens;  Schott, Bjorn H;  Buerger, Katharina;  Janowitz, Daniel;  Dichgans, Martin;  Perneczky, Robert;  Rauchmann, Boris-Stephan;  Teipel, Stefan;  Kilimann, Ingo;  Goerss, Doreen;  Laske, Christoph;  Munk, Matthias H;  Duzel, Emrah;  Yakupov, Renat;  Dobisch, Laura;  Metzger, Coraline D;  Glanz, Wenzel;  Ewers, Michael;  Dechent, Peter;  Haynes, John Dylan;  Scheffler, Klaus;  Roy, Nina;  Rostamzadeh, Ayda;  Teunissen, Charlotte E;  Marchant, Natalie L;  Spottke, Annika;  Jucker, Mathias;  Latz, Eicke;  Wagner, Michael;  Mengel, David;  Synofzik, Matthis;  Jessen, Frank;  Ramirez, Alfredo;  Ruiz, Agustin;  Heneka, Michael T;   - view fewer <#>    (2022)    Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease.                   Neuron , 110  (6)   pp. 1009-1022.    10.1016/j.neuron.2021.12.016 <https://doi.org/10.1016/j.neuron.2021.12.016>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10147406/2/Marchant_Brosseron_Maass_Kleineidam_20211210.pdf