@article{discovery10147406,
          volume = {110},
          number = {6},
           month = {March},
           title = {Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease},
         journal = {Neuron},
            year = {2022},
       publisher = {CELL PRESS},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
           pages = {1009--1022},
        keywords = {Alzheimer's disease; neuroinflammation; biomarker; TAM receptor},
        abstract = {There is an urgent need to improve the understanding of neuroinflammation in Alzheimer's disease (AD). We analyzed cerebrospinal fluid inflammatory biomarker correlations to brain structural volume and longitudinal cognitive outcomes in the DELCODE study and in a validation cohort of the F.ACE Alzheimer Center Barcelona. We investigated whether respective biomarker changes are evident before onset of cognitive impairment. YKL-40; sTREM2; sAXL; sTyro3; MIF; complement factors C1q, C4, and H; ferritin; and ApoE protein were elevated in pre-dementia subjects with pathological levels of tau or other neurodegeneration markers, demonstrating tight interactions between inflammation and accumulating neurodegeneration even before onset of symptoms. Intriguingly, higher levels of ApoE and soluble TAM receptors sAXL and sTyro3 were related to larger brain structure and stable cognitive outcome at follow-up. Our findings indicate a protective mechanism relevant for intervention strategies aiming to regulate neuroinflammation in subjects with no or subjective symptoms but underlying AD pathology profile.},
          author = {Brosseron, Frederic and Maass, Anne and Kleineidam, Luca and Ravichandran, Kishore Aravind and Gonzalez, Pablo Garcia and McManus, Roisin M and Ising, Christina and Santarelli, Francesco and Kolbe, Carl-Christian and Haesler, Lisa M and Wolfsgruber, Steffen and Marquie, Marta and Boada, Merce and Orellana, Adelina and de Rojas, Itziar and Roeske, Sandra and Peters, Oliver and Cosma, Nicoleta-Carmen and Cetindag, Arda and Wang, Xiao and Priller, Josef and Spruth, Eike J and Altenstein, Slawek and Schneider, Anja and Fliessbach, Klaus and Wiltfang, Jens and Schott, Bjorn H and Buerger, Katharina and Janowitz, Daniel and Dichgans, Martin and Perneczky, Robert and Rauchmann, Boris-Stephan and Teipel, Stefan and Kilimann, Ingo and Goerss, Doreen and Laske, Christoph and Munk, Matthias H and Duzel, Emrah and Yakupov, Renat and Dobisch, Laura and Metzger, Coraline D and Glanz, Wenzel and Ewers, Michael and Dechent, Peter and Haynes, John Dylan and Scheffler, Klaus and Roy, Nina and Rostamzadeh, Ayda and Teunissen, Charlotte E and Marchant, Natalie L and Spottke, Annika and Jucker, Mathias and Latz, Eicke and Wagner, Michael and Mengel, David and Synofzik, Matthis and Jessen, Frank and Ramirez, Alfredo and Ruiz, Agustin and Heneka, Michael T},
            issn = {0896-6273},
             url = {https://doi.org/10.1016/j.neuron.2021.12.016}
}