eprintid: 10147354 rev_number: 8 eprint_status: archive userid: 699 dir: disk0/10/14/73/54 datestamp: 2022-04-26 10:58:21 lastmod: 2024-10-24 09:52:30 status_changed: 2022-04-26 10:58:21 type: article metadata_visibility: show sword_depositor: 699 creators_name: Wenning, Gregor K creators_name: Stankovic, Iva creators_name: Vignatelli, Luca creators_name: Fanciulli, Alessandra creators_name: Calandra-Buonaura, Giovanna creators_name: Seppi, Klaus creators_name: Palma, Jose-Alberto creators_name: Meissner, Wassilios G creators_name: Krismer, Florian creators_name: Berg, Daniela creators_name: Cortelli, Pietro creators_name: Freeman, Roy creators_name: Halliday, Glenda creators_name: Höglinger, Günter creators_name: Lang, Anthony creators_name: Ling, Helen creators_name: Litvan, Irene creators_name: Low, Phillip creators_name: Miki, Yasuo creators_name: Panicker, Jalesh creators_name: Pellecchia, Maria Teresa creators_name: Quinn, Niall creators_name: Sakakibara, Ryuji creators_name: Stamelou, Maria creators_name: Tolosa, Eduardo creators_name: Tsuji, Shoji creators_name: Warner, Tom creators_name: Poewe, Werner creators_name: Kaufmann, Horacio title: The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy ispublished: inpress subjects: UCH divisions: C07 divisions: F84 divisions: B02 divisions: UCL divisions: D07 keywords: Diagnosis, diagnostic criteria, multiple system atrophy note: © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: BACKGROUND: The second consensus criteria for the diagnosis of multiple system atrophy (MSA) are widely recognized as the reference standard for clinical research, but lack sensitivity to diagnose the disease at early stages. OBJECTIVE: To develop novel Movement Disorder Society (MDS) criteria for MSA diagnosis using an evidence-based and consensus-based methodology. METHODS: We identified shortcomings of the second consensus criteria for MSA diagnosis and conducted a systematic literature review to answer predefined questions on clinical presentation and diagnostic tools relevant for MSA diagnosis. The criteria were developed and later optimized using two Delphi rounds within the MSA Criteria Revision Task Force, a survey for MDS membership, and a virtual Consensus Conference. RESULTS: The criteria for neuropathologically established MSA remain unchanged. For a clinical MSA diagnosis a new category of clinically established MSA is introduced, aiming for maximum specificity with acceptable sensitivity. A category of clinically probable MSA is defined to enhance sensitivity while maintaining specificity. A research category of possible prodromal MSA is designed to capture patients in the earliest stages when symptoms and signs are present, but do not meet the threshold for clinically established or clinically probable MSA. Brain magnetic resonance imaging markers suggestive of MSA are required for the diagnosis of clinically established MSA. The number of research biomarkers that support all clinical diagnostic categories will likely grow. CONCLUSIONS: This set of MDS MSA diagnostic criteria aims at improving the diagnostic accuracy, particularly in early disease stages. It requires validation in a prospective clinical and a clinicopathological study. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. date: 2022-04-21 date_type: published publisher: Wiley official_url: https://doi.org/10.1002/mds.29005 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1950473 doi: 10.1002/mds.29005 medium: Print-Electronic lyricists_name: Warner, Thomas lyricists_id: TTWAR25 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Movement Disorders event_location: United States citation: Wenning, Gregor K; Stankovic, Iva; Vignatelli, Luca; Fanciulli, Alessandra; Calandra-Buonaura, Giovanna; Seppi, Klaus; Palma, Jose-Alberto; ... Kaufmann, Horacio; + view all <#> Wenning, Gregor K; Stankovic, Iva; Vignatelli, Luca; Fanciulli, Alessandra; Calandra-Buonaura, Giovanna; Seppi, Klaus; Palma, Jose-Alberto; Meissner, Wassilios G; Krismer, Florian; Berg, Daniela; Cortelli, Pietro; Freeman, Roy; Halliday, Glenda; Höglinger, Günter; Lang, Anthony; Ling, Helen; Litvan, Irene; Low, Phillip; Miki, Yasuo; Panicker, Jalesh; Pellecchia, Maria Teresa; Quinn, Niall; Sakakibara, Ryuji; Stamelou, Maria; Tolosa, Eduardo; Tsuji, Shoji; Warner, Tom; Poewe, Werner; Kaufmann, Horacio; - view fewer <#> (2022) The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy. Movement Disorders 10.1002/mds.29005 <https://doi.org/10.1002/mds.29005>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10147354/1/Movement%20Disorders%20-%202022%20-%20Wenning.pdf