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<https://discovery.ucl.ac.uk/id/eprint/10147019> <http://purl.org/dc/terms/title> "Navigational Strategies and the Role of the Hippocampus in Mouse Escape Behaviour"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10147019> <http://purl.org/ontology/bibo/abstract> "Executing appropriate defensive actions is vital for survival. In mice,\r\nimminent threat elicits fast and accurate escape behaviour that relies on a rapidly formed spatial memory to reach shelter locations. I\r\ninvestigated the navigational strategies used by mice to navigate to\r\nsafety upon imminent threat, and the role of the hippocampal formation – classically associated with spatial representations – in guiding\r\nescape navigation. Through a series of behavioural experiments designed to distinguish between navigational strategies guiding escape,\r\nI found that while flight was consistent during the the first 800ms\r\nacross light and dark conditions, visual cues enabled faster, more efficient escape trajectories later on in flight, suggesting escape has two\r\nphases: orienting and accelerating towards the shelter, relying on a\r\nmemorised vector; and a second phase using vision to refine escape\r\ntrajectories. Accordingly, I found that path integration was necessary\r\nfor navigation in the dark, but not in the light. I next investigated the\r\ndependency of escape on brain structures associated with spatial representation in the hippocampal formation. An abrupt lesion targeted\r\nto the hippocampus using ibotenic acid disrupted escape navigation.\r\nA more targeted lesion of the primary hippocampal output - an infusion of muscimol into the subiculum – also led to a disruption of\r\nescape navigation and an increased propensity to freeze in response\r\nto looming visual stimuli. Finally, while disrupting neural activity in\r\nthe subiculum by stimulating with channelrhodopsin reduced acceleration, this effect was present with optogenetic stimulation alone,\r\nprecluding any firm conclusions from these experiments with respect\r\nto escape navigation. Together, these data further our knowledge of\r\ndefensive behaviours in mice by implicating high-level spatial representations of the environment in guiding escape navigation, identifying behavioural signatures of navigational strategies requiring these\r\nrepresentations, and showing the dependency of escape navigation\r\non brain regions associated with spatial representations."^^<http://www.w3.org/2001/XMLSchema#string> .
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