eprintid: 10146504
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/14/65/04
datestamp: 2022-04-06 16:23:19
lastmod: 2022-04-06 16:23:28
status_changed: 2022-04-06 16:23:19
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Naismith, Hamish
creators_name: Howard, Robert
creators_name: Stewart, Robert
creators_name: Pitman, Alexandra
creators_name: Mueller, Christoph
title: Suicidal ideation in dementia: associations with neuropsychiatric symptoms and subtype diagnosis
ispublished: inpress
divisions: C07
divisions: D79
divisions: B02
divisions: UCL
keywords: Alzheimer’s dementia, dementia, dementia with Lewy bodies, epidemiology, suicidal ideation, suicide, vascular dementia
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abstract: OBJECTIVES: To investigate factors associated with suicidal ideation (SI) around the time of dementia diagnosis. We hypothesised relatively preserved cognition, co-occurring physical and psychiatric disorders, functional impairments, and dementia diagnosis subtype would be associated with a higher risk of SI. DESIGN: Cross-sectional study using routinely collected electronic mental healthcare records. SETTING: National Health Service secondary mental healthcare services in South London, UK, serving a population of over 1.36 million residents. PARTICIPANTS: Patients who received a diagnosis of dementia (Alzheimer's, vascular, mixed Alzheimer's/vascular, or dementia with Lewy bodies) between 1 Nov 2007-31 Oct 2021: 18,252 people were identified during the observation period. MEASUREMENTS: A natural language processing algorithm was used to identify recorded clinician recording of SI around the time of dementia diagnosis. Sociodemographic and clinical characteristics were also measured around the time of diagnosis. We compared people diagnosed with non-Alzheimer's dementia to those with Alzheimer's and used statistical models to adjust for putative confounders. RESULTS: 15.1% of patients had recorded SI, which was more common in dementia with Lewy bodies compared to other dementia diagnoses studied. After adjusting for sociodemographic and clinical factors, SI was more frequent in those with depression and dementia with Lewy bodies and less common in those with impaired activities of daily living and in vascular dementia. Agitated behavior and hallucinations were not associated with SI in the final model. CONCLUSIONS: Our findings highlight the importance of identifying and treating depressive symptoms in people with dementia and the need for further research into under-researched dementia subtypes.
date: 2022-03-25
date_type: published
publisher: Cambridge University Press (CUP)
official_url: https://doi.org/10.1017/S1041610222000126
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1946936
doi: 10.1017/S1041610222000126
medium: Print-Electronic
pii: S1041610222000126
lyricists_name: Naismith, Hamish
lyricists_name: Pitman, Alexandra
lyricists_name: Howard, Robert
lyricists_id: HNAIS31
lyricists_id: APITM02
lyricists_id: RJMWH01
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: International Psychogeriatrics
event_location: England
citation:        Naismith, Hamish;    Howard, Robert;    Stewart, Robert;    Pitman, Alexandra;    Mueller, Christoph;      (2022)    Suicidal ideation in dementia: associations with neuropsychiatric symptoms and subtype diagnosis.                   International Psychogeriatrics        10.1017/S1041610222000126 <https://doi.org/10.1017/S1041610222000126>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10146504/1/Howard_Suicidal%20ideation%20in%20dementia_AOP.pdf