eprintid: 10146503
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/14/65/03
datestamp: 2022-04-06 16:28:20
lastmod: 2022-04-06 16:28:20
status_changed: 2022-04-06 16:28:20
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Abdel-Mannan, Omar
creators_name: Klein, Ainat
creators_name: Bachar Zipori, Anat
creators_name: Ben-Sira, Liat
creators_name: Fattal-Valevski, Aviva
creators_name: Hacohen, Yael
creators_name: Meirson, Hadas
title: Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder
ispublished: pub
divisions: C07
divisions: F87
divisions: B02
divisions: UCL
divisions: D07
keywords: Neuromyelitis optica spectrum disorder, aquaporin-4 antibody, paediatric demyelination, radiologically isolated syndrome
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abstract: Aquaporin-4 antibody (AQP4-Ab) Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare neuroinflammatory syndrome presenting predominantly with optic neuritis and transverse myelitis. We report a case of radiologically isolated longitudinally extensive optic neuritis in an asymptomatic 12-year-old female with positive serum AQP4-Ab, with resolution of imaging changes after immune therapy. By contrast to patients with radiologically isolated syndrome, of which some will never convert to multiple sclerosis, the pathogenicity of AQP4-Ab in the context of sub-clinical disease, supported treatment in our patient. Given the severe morbidity in AQP4-Ab NMOSD, prognostic biomarkers for disease severity are required to guide optimal therapy for patients.
date: 2022-04-01
date_type: published
publisher: SAGE Publications
official_url: https://doi.org/10.1177%2F13524585221074947
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1947031
doi: 10.1177/13524585221074947
medium: Print
lyricists_name: Abdel-Mannan, Omar
lyricists_id: OABDE15
actors_name: Barczynska, Patrycja
actors_id: PBARC91
actors_role: owner
full_text_status: public
publication: Multiple Sclerosis Journal
volume: 28
number: 4
pagerange: 676-679
event_location: England
citation:        Abdel-Mannan, Omar;    Klein, Ainat;    Bachar Zipori, Anat;    Ben-Sira, Liat;    Fattal-Valevski, Aviva;    Hacohen, Yael;    Meirson, Hadas;      (2022)    Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder.                   Multiple Sclerosis Journal , 28  (4)   pp. 676-679.    10.1177/13524585221074947 <https://doi.org/10.1177/13524585221074947>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10146503/1/Abdel-Mannan_13524585221074947.pdf