eprintid: 10146503 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/14/65/03 datestamp: 2022-04-06 16:28:20 lastmod: 2022-04-06 16:28:20 status_changed: 2022-04-06 16:28:20 type: article metadata_visibility: show sword_depositor: 699 creators_name: Abdel-Mannan, Omar creators_name: Klein, Ainat creators_name: Bachar Zipori, Anat creators_name: Ben-Sira, Liat creators_name: Fattal-Valevski, Aviva creators_name: Hacohen, Yael creators_name: Meirson, Hadas title: Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder ispublished: pub divisions: C07 divisions: F87 divisions: B02 divisions: UCL divisions: D07 keywords: Neuromyelitis optica spectrum disorder, aquaporin-4 antibody, paediatric demyelination, radiologically isolated syndrome note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ abstract: Aquaporin-4 antibody (AQP4-Ab) Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare neuroinflammatory syndrome presenting predominantly with optic neuritis and transverse myelitis. We report a case of radiologically isolated longitudinally extensive optic neuritis in an asymptomatic 12-year-old female with positive serum AQP4-Ab, with resolution of imaging changes after immune therapy. By contrast to patients with radiologically isolated syndrome, of which some will never convert to multiple sclerosis, the pathogenicity of AQP4-Ab in the context of sub-clinical disease, supported treatment in our patient. Given the severe morbidity in AQP4-Ab NMOSD, prognostic biomarkers for disease severity are required to guide optimal therapy for patients. date: 2022-04-01 date_type: published publisher: SAGE Publications official_url: https://doi.org/10.1177%2F13524585221074947 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1947031 doi: 10.1177/13524585221074947 medium: Print lyricists_name: Abdel-Mannan, Omar lyricists_id: OABDE15 actors_name: Barczynska, Patrycja actors_id: PBARC91 actors_role: owner full_text_status: public publication: Multiple Sclerosis Journal volume: 28 number: 4 pagerange: 676-679 event_location: England citation: Abdel-Mannan, Omar; Klein, Ainat; Bachar Zipori, Anat; Ben-Sira, Liat; Fattal-Valevski, Aviva; Hacohen, Yael; Meirson, Hadas; (2022) Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder. Multiple Sclerosis Journal , 28 (4) pp. 676-679. 10.1177/13524585221074947 <https://doi.org/10.1177/13524585221074947>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10146503/1/Abdel-Mannan_13524585221074947.pdf