TY  - JOUR
SP  - 2407
N2  - BACKGROUND AND AIMS: The accumulation of fat increases the formation of lipid peroxides, which are partly scavenged by alpha-tocopherol (?-TOH). Here, we aimed to investigate the associations between different measures of (abdominal) fat and levels of urinary ?-TOH metabolites in middle-aged individuals. METHODS AND RESULTS: In this cross-sectional analysis in the Netherlands Epidemiology of Obesity study (N = 511, 53% women; mean [SD] age of 55 [6.1] years), serum ?-TOH and ?-TOH metabolites from 24-h urine were measured as alpha-tocopheronolactone hydroquinone (?-TLHQ, oxidized) and alpha-carboxymethyl-hydroxychroman (?-CEHC, enzymatically converted) using liquid-chromatography-tandem mass spectrometry. Body mass index and total body fat were measured, and abdominal subcutaneous and visceral adipose tissue (aSAT and VAT) were assessed using magnetic resonance imaging. Using multivariable-adjusted linear regression analyses, we analysed the associations of BMI, TBF, aSAT and VAT with levels of urinary ?-TOH metabolites, adjusted for confounders. We observed no evidence for associations between body fat measures and serum ?-TOH. Higher BMI and TBF were associated with lower urinary levels of TLHQ (0.95 [95%CI: 0.90, 1.00] and 0.94 [0.88, 1.01] times per SD, respectively) and with lower TLHQ relative to CEHC (0.93 [0.90, 0.98] and 0.93 [0.87, 0.98] times per SD, respectively). We observed similar associations for VAT (TLHQ: 0.94 [0.89, 0.99] times per SD), but not for aSAT. CONCLUSIONS: Opposite to our research hypothesis, higher abdominal adiposity was moderately associated with lower levels of oxidized ?-TOH metabolites, which might reflect lower vitamin E antioxidative activity in individuals with higher abdominal fat instead.
A1  - Meulmeester, Fleur L
A1  - Luo, Jiao
A1  - Martens, Leon G
A1  - Ashrafi, Nadia
A1  - de Mutsert, Renee
A1  - Mook-Kanamori, Dennis O
A1  - Lamb, Hildo J
A1  - Rosendaal, Frits R
A1  - van Dijk, Ko Willems
A1  - Mills, Kevin
A1  - van Heemst, Diana
A1  - Noordam, Raymond
Y1  - 2021/07/09/
UR  - https://doi.org/10.1016/j.numecd.2021.05.001
TI  - Association of measures of body fat with serum alpha-tocopherol and its metabolites in middle-aged individuals
ID  - discovery10146106
AV  - public
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Cardiac & Cardiovascular Systems
KW  -  Endocrinology & Metabolism
KW  -  Nutrition & Dietetics
KW  -  Cardiovascular System & Cardiology
KW  -  Obesity
KW  -  Visceral adipose tissue
KW  -  Subcutaneous adipose tissue
KW  -  Vitamin E metabolites
KW  -  Alpha tocopherol
KW  -  Mass spectrometry
KW  -  Epidemiology
KW  -  OXIDATIVE STRESS
KW  -  VITAMIN-E
KW  -  OBESITY
KW  -  EXPRESSION
KW  -  PALMITATE
KW  -  ADULTS
KW  -  ACIDS
EP  - 2415
N1  - © 2021 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of
Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY license (http://creativecommons.
org/licenses/by/4.0/).
JF  - Nutrition, Metabolism & Cardiovascular Diseases
IS  - 8
VL  - 31
PB  - ELSEVIER SCI LTD
ER  -