<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10145983> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/title> "Broadly neutralizing antibody responses in the longitudinal primary HIV-1 infection Short Pulse Anti-Retroviral Therapy at Seroconversion cohort"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/abstract> "OBJECTIVE: Development of immunogens that elicit an anti-HIV-1 broadly neutralizing antibody (bnAb) response will be a key step in the development of an effective HIV-1 vaccine. Although HIV-1 bnAb epitopes have been identified and mechanisms of action studied, current HIV-1 envelope-based immunogens do not elicit HIV-1 bnAbs in humans or animal models. A better understanding of how HIV-1 bnAbs arise during infection and the clinical factors associated with bnAb development may be critical for HIV-1 immunogen design efforts. \r\n\r\nDESIGN AND METHODS: Longitudinal plasma samples from the treatment-naive control arm of the Short Pulse Anti-Retroviral Therapy at Seroconversion (SPARTAC) primary HIV-1 infection cohort were used in an HIV-1 pseudotype neutralization assay to measure the neutralization breadth, potency and specificity of bnAb responses over time. \r\n\r\nRESULTS: In the SPARTAC cohort, development of plasma neutralization breadth and potency correlates with duration of HIV infection and high viral loads, and typically takes 3-4 years to arise. bnAb activity was mostly directed to one or two bnAb epitopes per donor and more than 60% of donors with the highest plasma neutralization having bnAbs targeted towards glycan-dependent epitopes. \r\n\r\nCONCLUSION: This study highlights the SPARTAC cohort as an important resource for more in-depth analysis of bnAb developmental pathways."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/date> "2021-11-01" . <https://discovery.ucl.ac.uk/id/document/1460755> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/volume> "35" . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/issue> "13" . <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> <http://xmlns.com/foaf/0.1/name> "LIPPINCOTT WILLIAMS & WILKINS"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> . <https://discovery.ucl.ac.uk/id/publication/ext-02699370> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-02699370> <http://xmlns.com/foaf/0.1/name> "AIDS"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-02699370> . <https://discovery.ucl.ac.uk/id/publication/ext-02699370> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:02699370> . <https://discovery.ucl.ac.uk/id/publication/ext-02699370> <http://purl.org/ontology/bibo/issn> "02699370" . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-752dbf3414fefb8128d2a66d9e308715> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-752dbf3414fefb8128d2a66d9e308715> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-659767983637dbb2b5bab93d8fae4569> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-659767983637dbb2b5bab93d8fae4569> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a26f33b430152e91b306d5740c243de8> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-a26f33b430152e91b306d5740c243de8> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c146333091d61c9112841b2fe6c94846> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-c146333091d61c9112841b2fe6c94846> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9460ea502ca997b0ccad90613c5e316f> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-9460ea502ca997b0ccad90613c5e316f> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9b23bc788dcd2628f1f21f5cdd7f7863> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-9b23bc788dcd2628f1f21f5cdd7f7863> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b2db4ef0249cbb93a1328b4ba62aaf9e> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-b2db4ef0249cbb93a1328b4ba62aaf9e> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2c81c3db102b0e2b42b47ea7253968b1> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-2c81c3db102b0e2b42b47ea7253968b1> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-be336f083b3f214e337313084c96fae7> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-be336f083b3f214e337313084c96fae7> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-75a64ae597cd1857261e228ee8a55ec4> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-75a64ae597cd1857261e228ee8a55ec4> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-796756ffebc4306d18954e4e98a5f133> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-796756ffebc4306d18954e4e98a5f133> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fa5334a081e317f01e466d67e7004d2e> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-fa5334a081e317f01e466d67e7004d2e> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-097518c5e589ed75eb3b10c8c0edb396> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-097518c5e589ed75eb3b10c8c0edb396> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f899ac1e329680898edd7a61c1f465e8> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-f899ac1e329680898edd7a61c1f465e8> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eff13fa2baa64a227726db1ec3a7e17d> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-eff13fa2baa64a227726db1ec3a7e17d> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-500800d291b83180a392c58a0803f205> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-500800d291b83180a392c58a0803f205> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3c50f0c7f3104b780c9025610fa28549> . <https://discovery.ucl.ac.uk/id/eprint/10145983> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> . <https://discovery.ucl.ac.uk/id/eprint/10145983#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-3c50f0c7f3104b780c9025610fa28549> . <https://discovery.ucl.ac.uk/id/person/ext-75a64ae597cd1857261e228ee8a55ec4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-75a64ae597cd1857261e228ee8a55ec4> <http://xmlns.com/foaf/0.1/givenName> "Abdel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-75a64ae597cd1857261e228ee8a55ec4> <http://xmlns.com/foaf/0.1/familyName> "Babiker"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-75a64ae597cd1857261e228ee8a55ec4> <http://xmlns.com/foaf/0.1/name> "Abdel Babiker"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-796756ffebc4306d18954e4e98a5f133> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-796756ffebc4306d18954e4e98a5f133> <http://xmlns.com/foaf/0.1/givenName> "David A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-796756ffebc4306d18954e4e98a5f133> <http://xmlns.com/foaf/0.1/familyName> "Cooper"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-796756ffebc4306d18954e4e98a5f133> <http://xmlns.com/foaf/0.1/name> "David A Cooper"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-752dbf3414fefb8128d2a66d9e308715> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-752dbf3414fefb8128d2a66d9e308715> <http://xmlns.com/foaf/0.1/givenName> "Luke A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-752dbf3414fefb8128d2a66d9e308715> <http://xmlns.com/foaf/0.1/familyName> "Granger"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-752dbf3414fefb8128d2a66d9e308715> <http://xmlns.com/foaf/0.1/name> "Luke A Granger"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f899ac1e329680898edd7a61c1f465e8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f899ac1e329680898edd7a61c1f465e8> <http://xmlns.com/foaf/0.1/givenName> "Sarah"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f899ac1e329680898edd7a61c1f465e8> <http://xmlns.com/foaf/0.1/familyName> "Fidler"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f899ac1e329680898edd7a61c1f465e8> <http://xmlns.com/foaf/0.1/name> "Sarah Fidler"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-500800d291b83180a392c58a0803f205> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-500800d291b83180a392c58a0803f205> <http://xmlns.com/foaf/0.1/givenName> "Julie"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-500800d291b83180a392c58a0803f205> <http://xmlns.com/foaf/0.1/familyName> "Fox"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-500800d291b83180a392c58a0803f205> <http://xmlns.com/foaf/0.1/name> "Julie Fox"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fa5334a081e317f01e466d67e7004d2e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-fa5334a081e317f01e466d67e7004d2e> <http://xmlns.com/foaf/0.1/givenName> "Martin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fa5334a081e317f01e466d67e7004d2e> <http://xmlns.com/foaf/0.1/familyName> "Fisher"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fa5334a081e317f01e466d67e7004d2e> <http://xmlns.com/foaf/0.1/name> "Martin Fisher"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9460ea502ca997b0ccad90613c5e316f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9460ea502ca997b0ccad90613c5e316f> <http://xmlns.com/foaf/0.1/givenName> "Mauro"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9460ea502ca997b0ccad90613c5e316f> <http://xmlns.com/foaf/0.1/familyName> "Schechter"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9460ea502ca997b0ccad90613c5e316f> <http://xmlns.com/foaf/0.1/name> "Mauro Schechter"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a26f33b430152e91b306d5740c243de8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a26f33b430152e91b306d5740c243de8> <http://xmlns.com/foaf/0.1/givenName> "Franka"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a26f33b430152e91b306d5740c243de8> <http://xmlns.com/foaf/0.1/familyName> "Debeljak"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a26f33b430152e91b306d5740c243de8> <http://xmlns.com/foaf/0.1/name> "Franka 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