eprintid: 10145256 rev_number: 29 eprint_status: archive userid: 699 dir: disk0/10/14/52/56 datestamp: 2022-03-18 10:46:19 lastmod: 2023-01-10 15:24:21 status_changed: 2023-01-10 15:24:21 type: article metadata_visibility: show sword_depositor: 699 creators_name: Bermingham, Charlotte creators_name: Morgan, Jasper creators_name: Ayoubkhani, Daniel creators_name: Glickman, Myer creators_name: Islan, Hazrul creators_name: Sheikh, Aziz creators_name: Sterne, Jonathan creators_name: Walker, Ann creators_name: Nafilyan, Vahe title: Estimating the effectiveness of first dose of COVID-19 vaccine against mortality in England: a quasi-experimental study ispublished: pub divisions: UCL divisions: J38 divisions: D65 divisions: B02 note: © 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: Several studies reported hematological abnormalities after vaccination against the coronavirus disease 2019 (COVID-19). We evaluated the association between COVID-19 vaccines (CoronaVac and BNT162b2) and hematological abnormalities. We conducted nested case–control and self-controlled case series analyses using the data from the Hong Kong Hospital Authority and the Department of Health, HKSAR. Outcomes of interest were thrombocytopenia, leukopenia, and neutropenia. Adjusted odds ratios (aORs), incidence rate ratios (IRRs), and 95% confidence intervals (CIs) were estimated using conditional logistic regression. In total, 1 643 419 people received COVID-19 vaccination (738 609 CoronaVac; 904 810 BNT162b2). We identified 457 and 422 cases after CoronaVac and BNT162b2 vaccination, respectively. For CoronaVac, the incidence of thrombocytopenia, leukopenia, and neutropenia was 2.51, 1.08, and 0.15 per 10 000 doses. For BNT162b2, the corresponding incidence was 1.39, 1.17, and 0.26 per 10 000 doses. The incidence per 10 000 COVID-19 cases were 1254, 2341, and 884, respectively. We only observed an increased risk of leukopenia following the second dose of BNT162b2 (aOR 1.58, 95% CI 1.24–2.02; day 0–14, IRR 2.21; 95% CI 1.59–3.08). There was no increased risk of any hematological abnormalities after CoronaVac vaccination. We observed an increased risk of leukopenia shortly after the second dose of BNT162b2. However, the incidence was much lower than the incidence following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. There was no association between CoronaVac and hematological abnormalities. The benefits of vaccination against COVID-19 still outweigh the risk of hematological abnormalities. date: 2022-04 date_type: published publisher: Oxford University Press (OUP) official_url: https://doi.org/10.1002/ajh.26478 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1945017 doi: 10.1002/ajh.26478 lyricists_name: Walker, Ann lyricists_id: ASWAL40 actors_name: Walker, Ann actors_id: ASWAL40 actors_role: owner full_text_status: public publication: American Journal of Epidemiology volume: 97 number: 4 pagerange: 470-480 citation: Bermingham, Charlotte; Morgan, Jasper; Ayoubkhani, Daniel; Glickman, Myer; Islan, Hazrul; Sheikh, Aziz; Sterne, Jonathan; ... Nafilyan, Vahe; + view all <#> Bermingham, Charlotte; Morgan, Jasper; Ayoubkhani, Daniel; Glickman, Myer; Islan, Hazrul; Sheikh, Aziz; Sterne, Jonathan; Walker, Ann; Nafilyan, Vahe; - view fewer <#> (2022) Estimating the effectiveness of first dose of COVID-19 vaccine against mortality in England: a quasi-experimental study. American Journal of Epidemiology , 97 (4) pp. 470-480. 10.1002/ajh.26478 <https://doi.org/10.1002/ajh.26478>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10145256/17/Walker_American%20J%20Hematol%20-%202022%20-%20Sing%20-%20COVID%E2%80%9019%20vaccines%20and%20risks%20of%20hematological%20abnormalities%20%20Nested%20case%20control%20and.pdf