eprintid: 10144432 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/14/44/32 datestamp: 2022-03-02 14:36:24 lastmod: 2022-03-02 14:36:24 status_changed: 2022-03-02 14:36:24 type: article metadata_visibility: show sword_depositor: 699 creators_name: Baev, Artyom Y creators_name: Vinokurov, Andrey Y creators_name: Novikova, Irina N creators_name: Dremin, Viktor V creators_name: Potapova, Elena V creators_name: Abramov, Andrey Y title: Interaction of Mitochondrial Calcium and ROS in Neurodegeneration ispublished: pub divisions: C07 divisions: F84 divisions: B02 divisions: UCL divisions: D07 keywords: neurodegeneration; mitochondria; calcium; reactive oxygen species; cell death; permeability transition pore; neuron note: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: Neurodegenerative disorders are currently incurable devastating diseases which are characterized by the slow and progressive loss of neurons in specific brain regions. Progress in the investigation of the mechanisms of these disorders helped to identify a number of genes associated with familial forms of these diseases and a number of toxins and risk factors which trigger sporadic and toxic forms of these diseases. Recently, some similarities in the mechanisms of neurodegenerative diseases were identified, including the involvement of mitochondria, oxidative stress, and the abnormality of Ca2+ signaling in neurons and astrocytes. Thus, mitochondria produce reactive oxygen species during metabolism which play a further role in redox signaling, but this may also act as an additional trigger for abnormal mitochondrial calcium handling, resulting in mitochondrial calcium overload. Combinations of these factors can be the trigger of neuronal cell death in some pathologies. Here, we review the latest literature on the crosstalk of reactive oxygen species and Ca2+ in brain mitochondria in physiology and beyond, considering how changes in mitochondrial metabolism or redox signaling can convert this interaction into a pathological event. date: 2022-02-17 date_type: published publisher: MDPI AG official_url: https://doi.org/10.3390/cells11040706 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1941802 doi: 10.3390/cells11040706 lyricists_name: Abramov, Andrey lyricists_id: AABRA58 actors_name: Kalinowski, Damian actors_id: DKALI47 actors_role: owner full_text_status: public publication: Cells volume: 11 number: 4 article_number: 706 citation: Baev, Artyom Y; Vinokurov, Andrey Y; Novikova, Irina N; Dremin, Viktor V; Potapova, Elena V; Abramov, Andrey Y; (2022) Interaction of Mitochondrial Calcium and ROS in Neurodegeneration. Cells , 11 (4) , Article 706. 10.3390/cells11040706 <https://doi.org/10.3390/cells11040706>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10144432/1/Abramov_Interaction%20of%20Mitochondrial%20Calcium%20and%20ROS%20in%20Neurodegeneration_VoR.pdf