eprintid: 10144432
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/14/44/32
datestamp: 2022-03-02 14:36:24
lastmod: 2022-03-02 14:36:24
status_changed: 2022-03-02 14:36:24
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Baev, Artyom Y
creators_name: Vinokurov, Andrey Y
creators_name: Novikova, Irina N
creators_name: Dremin, Viktor V
creators_name: Potapova, Elena V
creators_name: Abramov, Andrey Y
title: Interaction of Mitochondrial Calcium and ROS in Neurodegeneration
ispublished: pub
divisions: C07
divisions: F84
divisions: B02
divisions: UCL
divisions: D07
keywords: neurodegeneration; mitochondria; calcium; reactive oxygen species; cell death; permeability transition pore; neuron
note: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Neurodegenerative disorders are currently incurable devastating diseases which are characterized by the slow and progressive loss of neurons in specific brain regions. Progress in the investigation of the mechanisms of these disorders helped to identify a number of genes associated with familial forms of these diseases and a number of toxins and risk factors which trigger sporadic and toxic forms of these diseases. Recently, some similarities in the mechanisms of neurodegenerative diseases were identified, including the involvement of mitochondria, oxidative stress, and the abnormality of Ca2+ signaling in neurons and astrocytes. Thus, mitochondria produce reactive oxygen species during metabolism which play a further role in redox signaling, but this may also act as an additional trigger for abnormal mitochondrial calcium handling, resulting in mitochondrial calcium overload. Combinations of these factors can be the trigger of neuronal cell death in some pathologies. Here, we review the latest literature on the crosstalk of reactive oxygen species and Ca2+ in brain mitochondria in physiology and beyond, considering how changes in mitochondrial metabolism or redox signaling can convert this interaction into a pathological event.
date: 2022-02-17
date_type: published
publisher: MDPI AG
official_url: https://doi.org/10.3390/cells11040706
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1941802
doi: 10.3390/cells11040706
lyricists_name: Abramov, Andrey
lyricists_id: AABRA58
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: Cells
volume: 11
number: 4
article_number: 706
citation:        Baev, Artyom Y;    Vinokurov, Andrey Y;    Novikova, Irina N;    Dremin, Viktor V;    Potapova, Elena V;    Abramov, Andrey Y;      (2022)    Interaction of Mitochondrial Calcium and ROS in Neurodegeneration.                   Cells , 11  (4)    , Article 706.  10.3390/cells11040706 <https://doi.org/10.3390/cells11040706>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10144432/1/Abramov_Interaction%20of%20Mitochondrial%20Calcium%20and%20ROS%20in%20Neurodegeneration_VoR.pdf