eprintid: 10144401
rev_number: 10
eprint_status: archive
userid: 699
dir: disk0/10/14/44/01
datestamp: 2022-03-02 10:29:03
lastmod: 2022-08-17 06:10:24
status_changed: 2022-03-02 10:29:03
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Bonati, LH
creators_name: Jansen, O
creators_name: de Borst, GJ
creators_name: Brown, MM
title: Management of atherosclerotic extracranial carotid artery stenosis
ispublished: pub
divisions: C07
divisions: D07
divisions: B02
divisions: UCL
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: Atherosclerosis leading to stenosis of the internal carotid artery is the underlying cause of 8–15% of ischaemic strokes (symptomatic carotid stenosis). 1–2% of the adult population have asymptomatic carotid stenosis. Clinical trials in patients with symptomatic carotid stenosis showed a higher procedural risk of non-disabling stroke with stenting versus endarterectomy, but a higher risk of myocardial infarction, cranial nerve palsy, and access site haematoma with endarterectomy. Apart from procedural complications, both treatments are equally effective in preventing stroke and recurrent severe carotid stenosis in the medium-to-long term. Endarterectomy has a modest effect in preventing stroke among patients with asymptomatic carotid stenosis, whereas the role of stenting remains to be established. With advances in medical therapy against atherosclerosis, benefit from invasive therapy has become uncertain. Risk modelling, with the inclusion of brain and carotid plaque imaging, will become increasingly important in selecting patients for interventions.
date: 2022-03-01
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/S1474-4422(21)00359-8
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1942461
doi: 10.1016/S1474-4422(21)00359-8
pii: S1474-4422(21)00359-8
lyricists_name: Brown, Martin
lyricists_id: MMBRO52
actors_name: Brown, Martin
actors_id: MMBRO52
actors_role: owner
full_text_status: public
publication: The Lancet Neurology
volume: 21
number: 3
pagerange: 273-283
event_location: England
citation:        Bonati, LH;    Jansen, O;    de Borst, GJ;    Brown, MM;      (2022)    Management of atherosclerotic extracranial carotid artery stenosis.                   The Lancet Neurology , 21  (3)   pp. 273-283.    10.1016/S1474-4422(21)00359-8 <https://doi.org/10.1016/S1474-4422%2821%2900359-8>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10144401/3/Brown_Management%20of%20atherosclerotic%20extracranial%20carotid%20artery%20stenosis_AAM.pdf