@article{discovery10144042,
            year = {2022},
           title = {Studying the post-COVID-19 condition: research challenges, strategies, and importance of Core Outcome Set development},
         journal = {BMC Medicine},
          number = {1},
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          volume = {20},
           month = {February},
       publisher = {BMC},
        keywords = {Science \& Technology, Life Sciences \& Biomedicine, Medicine, General \& Internal, General \& Internal Medicine, COVID-19, COVID-19 sequalae, Long COVID, Post-acute sequelae of SARS-CoV-2 infection, PASC, Post-COVID-19 condition, Outcomes, Core Outcome Set, RESPIRATORY-FAILURE, SURVIVORS},
          author = {Munblit, Daniel and Nicholson, Timothy R and Needham, Dale M and Seylanova, Nina and Parr, Callum and Chen, Jessica and Kokorina, Alisa and Sigfrid, Louise and Buonsenso, Danilo and Bhatnagar, Shinjini and Thiruvengadam, Ramachandran and Parker, Ann M and Preller, Jacobus and Avdeev, Sergey and Klok, Frederikus A and Tong, Allison and Diaz, Janet V and De Groote, Wouter and Schiess, Nicoline and Akrami, Athena and Simpson, Frances and Olliaro, Piero and Apfelbacher, Christian and Rosa, Regis Goulart and Chevinsky, Jennifer R and Saydah, Sharon and Schmitt, Jochen and Guekht, Alla and Gorst, Sarah L and Genuneit, Jon and Reyes, Luis Felipe and Asmanov, Alan and O'Hara, Margaret E and Scott, Janet T and Michelen, Melina and Stavropoulou, Charitini and Warner, John O and Herridge, Margaret and Williamson, Paula R},
             url = {https://doi.org/10.1186/s12916-021-02222-y},
        abstract = {BACKGROUND: A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to as long COVID but also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-COVID-19 condition, could become a significant global health burden. MAIN TEXT: While the number of studies investigating the post-COVID-19 condition is increasing, there is no agreement on how this new disease should be defined and diagnosed in clinical practice and what relevant outcomes to measure. There is an urgent need to optimise and standardise outcome measures for this important patient group both for clinical services and for research and to allow comparing and pooling of data. CONCLUSIONS: A Core Outcome Set for post-COVID-19 condition should be developed in the shortest time frame possible, for improvement in data quality, harmonisation, and comparability between different geographical locations. We call for a global initiative, involving all relevant partners, including, but not limited to, healthcare professionals, researchers, methodologists, patients, and caregivers. We urge coordinated actions aiming to develop a Core Outcome Set (COS) for post-COVID-19 condition in both the adult and paediatric populations.}
}