eprintid: 10143749
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/14/37/49
datestamp: 2022-02-17 17:49:56
lastmod: 2022-02-17 17:49:56
status_changed: 2022-02-17 17:49:56
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Gil Rosa, B
creators_name: Akingbade, OE
creators_name: Guo, X
creators_name: Gonzalez-Macia, L
creators_name: Crone, MA
creators_name: Cameron, LP
creators_name: Freemont, P
creators_name: Choy, KL
creators_name: Güder, F
creators_name: Yeatman, E
creators_name: Sharp, DJ
creators_name: Li, B
title: Multiplexed immunosensors for point-of-care diagnostic applications
ispublished: pub
divisions: C06
divisions: ZZN
divisions: B04
divisions: UCL
divisions: F62
note: Copyright © 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
abstract: Accurate, reliable, and cost-effective immunosensors are clinically important for the early diagnosis and monitoring of progressive diseases, and multiplexed sensing is a promising strategy for the next generation of diagnostics. This strategy allows for the simultaneous detection and quantification of multiple biomarkers with significantly enhanced reproducibility and reliability, whilst requiring smaller sample volumes, fewer materials, and shorter average analysis time for individual biomarkers than individual tests. In this opinionated review, we compare different techniques for the development of multiplexed immunosensors. We review the state-of-the-art approaches in the field of multiplexed immunosensors using electrical, electrochemical, and optical methods. The barriers that prevent translating this sensing strategy into clinics are outlined together with the potential solutions. We also share our vision on how multiplexed immunosensors will continue their evolution in the coming years.
date: 2022-05-01
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.bios.2022.114050
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1939280
doi: 10.1016/j.bios.2022.114050
lyricists_name: Li, Bing
lyricists_id: BLICX39
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Biosensors and Bioelectronics
volume: 203
article_number: 114050
citation:        Gil Rosa, B;    Akingbade, OE;    Guo, X;    Gonzalez-Macia, L;    Crone, MA;    Cameron, LP;    Freemont, P;                     ... Li, B; + view all <#>        Gil Rosa, B;  Akingbade, OE;  Guo, X;  Gonzalez-Macia, L;  Crone, MA;  Cameron, LP;  Freemont, P;  Choy, KL;  Güder, F;  Yeatman, E;  Sharp, DJ;  Li, B;   - view fewer <#>    (2022)    Multiplexed immunosensors for point-of-care diagnostic applications.                   Biosensors and Bioelectronics , 203     , Article 114050.  10.1016/j.bios.2022.114050 <https://doi.org/10.1016/j.bios.2022.114050>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10143749/1/1-s2.0-S0956566322000902-main.pdf