eprintid: 10143627
rev_number: 15
eprint_status: archive
userid: 699
dir: disk0/10/14/36/27
datestamp: 2022-02-17 14:06:14
lastmod: 2023-03-22 07:10:04
status_changed: 2023-01-11 14:40:07
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Nakamura, Carina Akemi
creators_name: Mitchell, Paul M
creators_name: Peters, Tim J
creators_name: Moreno-Agostino, Darío
creators_name: Araya, Ricardo
creators_name: Scazufca, Marcia
creators_name: Hollingworth, William
title: A validation study of the EQ-5D-5L and ICECAP-O among older individuals with depressive symptoms in Brazil
ispublished: pub
divisions: B14
divisions: J81
divisions: B16
divisions: UCL
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: Objectives: This study aimed to assess the known-groups validity of the EQ-5D-5L and the ICECAP-O,  two outcome measures used in economic evaluation, among older adults with depressive symptoms in socio-economically deprived areas of Brazil. We also explored the role of education and income on responses to these measures.
Methods: This cross-sectional study used baseline data from PROACTIVE, a cluster randomised controlled trial to evaluate a psychosocial intervention for late life depression among older adults. Participants aged 60 years or over with a Patient Health Questionnaire (PHQ-9) score≥10 were recruited from 20 primary healthcare clinics. Ordered logistic regression models assessed the association between depression severity, income and education and dimension level responses on the EQ-5D-5L and ICECAP-O. Multivariable regression models investigated the ability of EQ-5D-5L and ICECAP-O scores to discriminate between depression severity levels and other characteristics, including education level and household income. 
Results: 715 participants were included in the study. Depression severity was associated with all EQ-5D-5L and ICECAP-O dimensions, except the ICECAP-O enjoyment attribute. Household income, on the other hand, was only associated with the ICECAP-O security attribute. Higher severity of depressive symptoms (PHQ-9 scores) were also strongly associated with lower (i.e. worse) scores on both measures in all models. Education level and household income showed no association with either EQ-5D-5L or ICECAP-O scores.  
Conclusions: This is the first study that investigated the validity of these two measures among older adults in Brazil. Both EQ-5D-5L and ICECAP-O showed evidence of validity in differentiating depressive symptom severity.
date: 2022-07
date_type: published
publisher: Elsevier
official_url: https://doi.org/10.1016/j.vhri.2021.11.005
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1939803
doi: 10.1016/j.vhri.2021.11.005
lyricists_name: Moreno Agostino, Dario
lyricists_id: DMORE92
actors_name: Moreno Agostino, Dario
actors_id: DMORE92
actors_role: owner
funding_acknowledgements: 17/50094-2 [São Paulo Research Foundation]; MR/R006229/1 [Joint Global Health Trials initiative]; 2018/19343-0 [São Paulo Research Foundation]; 205384/Z/16/Z [Wellcome Trust]; 307579/2-19-0 [CNPq-Brazil]
full_text_status: public
publication: Value in Health Regional Issues
volume: 30
pagerange: 91-99
citation:        Nakamura, Carina Akemi;    Mitchell, Paul M;    Peters, Tim J;    Moreno-Agostino, Darío;    Araya, Ricardo;    Scazufca, Marcia;    Hollingworth, William;      (2022)    A validation study of the EQ-5D-5L and ICECAP-O among older individuals with depressive symptoms in Brazil.                   Value in Health Regional Issues , 30    pp. 91-99.    10.1016/j.vhri.2021.11.005 <https://doi.org/10.1016/j.vhri.2021.11.005>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10143627/1/Accepted%20author%20manuscript.pdf