@article{discovery10143627,
           month = {July},
            year = {2022},
           pages = {91--99},
           title = {A validation study of the EQ-5D-5L and ICECAP-O among older individuals with depressive symptoms in Brazil},
       publisher = {Elsevier},
          volume = {30},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
         journal = {Value in Health Regional Issues},
          author = {Nakamura, Carina Akemi and Mitchell, Paul M and Peters, Tim J and Moreno-Agostino, Dar{\'i}o and Araya, Ricardo and Scazufca, Marcia and Hollingworth, William},
             url = {https://doi.org/10.1016/j.vhri.2021.11.005},
        abstract = {Objectives: This study aimed to assess the known-groups validity of the EQ-5D-5L and the ICECAP-O,  two outcome measures used in economic evaluation, among older adults with depressive symptoms in socio-economically deprived areas of Brazil. We also explored the role of education and income on responses to these measures.
Methods: This cross-sectional study used baseline data from PROACTIVE, a cluster randomised controlled trial to evaluate a psychosocial intervention for late life depression among older adults. Participants aged 60 years or over with a Patient Health Questionnaire (PHQ-9) score{$\ge$}10 were recruited from 20 primary healthcare clinics. Ordered logistic regression models assessed the association between depression severity, income and education and dimension level responses on the EQ-5D-5L and ICECAP-O. Multivariable regression models investigated the ability of EQ-5D-5L and ICECAP-O scores to discriminate between depression severity levels and other characteristics, including education level and household income. 
Results: 715 participants were included in the study. Depression severity was associated with all EQ-5D-5L and ICECAP-O dimensions, except the ICECAP-O enjoyment attribute. Household income, on the other hand, was only associated with the ICECAP-O security attribute. Higher severity of depressive symptoms (PHQ-9 scores) were also strongly associated with lower (i.e. worse) scores on both measures in all models. Education level and household income showed no association with either EQ-5D-5L or ICECAP-O scores.  
Conclusions: This is the first study that investigated the validity of these two measures among older adults in Brazil. Both EQ-5D-5L and ICECAP-O showed evidence of validity in differentiating depressive symptom severity.}
}