%0 Journal Article
%A Hazan, Jemma
%A Alston, Duncan
%A Fox, Nick C
%A Howard, Robert
%D 2022
%F discovery:10143524
%I John Wiley and Sons
%J International Journal of Geriatric Psychiatry
%K Alzheimer's disease, biomarker, diagnosis, p-tau181
%N 2
%T Practical application of Alzheimer's Disease Neuroimaging Initiative plasma P-tau181 reference data to support diagnosis of Alzheimer's disease
%U https://discovery.ucl.ac.uk/id/eprint/10143524/
%V 37
%X OBJECTIVES: To assess plasma phosphorylated tau181 (p-tau181) levels in Alzheimer's disease (AD), cognitively impaired non-AD participants (CI non-AD) and Control participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset that could potentially act as reference data for clinic diagnoses of AD. METHODS: Data from 1558 participants (649 AD participants, 445 CI non-AD participants and 464 controls) were examined, comparing p-tau181 levels between Controls, AD and other dementias, stratified by age. RESULTS: There were significant differences in plasma p-tau181 values between Controls and those with AD at all ages up to 85 years. There were also significant differences between AD and CI non-AD participants up to the age of 85 years. CONCLUSIONS: Plasma P-tau181 may be a useful tool in the diagnosis of AD in those clinical settings where biomarkers have traditionally been less used. P-tau181 may be less useful as an aid to diagnosis in the very oldest-old. Further work is needed to establish the feasibility and utility of this biomarker within dementia diagnosis services not led by Neurologists, such as UK National Health Service Memory Services.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.