eprintid: 10143243
rev_number: 16
eprint_status: archive
userid: 699
dir: disk0/10/14/32/43
datestamp: 2022-02-10 14:24:47
lastmod: 2023-02-03 10:45:17
status_changed: 2022-02-10 14:24:47
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Erro, Roberto
creators_name: Fasano, Alfonso
creators_name: Barone, Paolo
creators_name: Bhatia, Kailash P
title: Milestones in Tremor Research: 10 Years Later
ispublished: pub
divisions: C07
divisions: F84
divisions: B02
divisions: UCL
divisions: D07
keywords: Essential tremor, dystonic tremor, parkinson disease, sensors, MRgFUS
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions
abstract: Major progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized Essential Tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances have been obtained in terms of instrumental measurement of tremor, remarking on the possibility of developing novel treatment strategies based on tremor characteristics, namely tremor-phase. Moreover, a better understanding of the pathophysiological mechanisms has further led to the suggestion of refining the classification of tremor syndromes according to their driving underpinnings. Finally, surgical options such as deep brain stimulation and focused ultrasound thalamotomy are now part of the therapeutic portfolio for tremor, but several oral drugs, including long-chain alcohols, T-channel blockers, allosteric modulators of potassium channels and of GABA-A receptors, are currently being tested and hold promise. This review will discuss the key milestones in tremor research of the last ten years, with a focus on the most common tremor syndromes, namely Essential Tremor, Dystonic Tremor and Parkinsonian Tremor.
date: 2022-05
date_type: published
publisher: Wiley
official_url: https://doi.org/10.1002/mdc3.13418
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1938220
doi: 10.1002/mdc3.13418
lyricists_name: Bhatia, Kailash
lyricists_id: KPBHA96
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Movement Disorders Clinical Practice
volume: 9
number: 4
pagerange: 429-435
citation:        Erro, Roberto;    Fasano, Alfonso;    Barone, Paolo;    Bhatia, Kailash P;      (2022)    Milestones in Tremor Research: 10 Years Later.                   Movement Disorders Clinical Practice , 9  (4)   pp. 429-435.    10.1002/mdc3.13418 <https://doi.org/10.1002/mdc3.13418>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10143243/7/Bhatia_Movement%20Disord%20Clin%20Pract%20-%202022%20-%20Erro%20-%20Milestones%20in%20Tremor%20Research%20%2010%20Years%20Later.pdf