TY  - JOUR
KW  - Essential tremor
KW  -  dystonic tremor
KW  -  parkinson disease
KW  -  sensors
KW  -  MRgFUS
TI  - Milestones in Tremor Research: 10?Years Later
SP  - 429
UR  - https://doi.org/10.1002/mdc3.13418
VL  - 9
N2  - Major progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized Essential Tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances have been obtained in terms of instrumental measurement of tremor, remarking on the possibility of developing novel treatment strategies based on tremor characteristics, namely tremor-phase. Moreover, a better understanding of the pathophysiological mechanisms has further led to the suggestion of refining the classification of tremor syndromes according to their driving underpinnings. Finally, surgical options such as deep brain stimulation and focused ultrasound thalamotomy are now part of the therapeutic portfolio for tremor, but several oral drugs, including long-chain alcohols, T-channel blockers, allosteric modulators of potassium channels and of GABA-A receptors, are currently being tested and hold promise. This review will discuss the key milestones in tremor research of the last ten years, with a focus on the most common tremor syndromes, namely Essential Tremor, Dystonic Tremor and Parkinsonian Tremor.
EP  - 435
JF  - Movement Disorders Clinical Practice
AV  - public
ID  - discovery10143243
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions
A1  - Erro, Roberto
A1  - Fasano, Alfonso
A1  - Barone, Paolo
A1  - Bhatia, Kailash P
Y1  - 2022/05//
PB  - Wiley
IS  - 4
ER  -