eprintid: 10143014
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/14/30/14
datestamp: 2022-02-07 15:37:38
lastmod: 2022-02-07 15:37:38
status_changed: 2022-02-07 15:37:38
type: proceedings_section
metadata_visibility: show
sword_depositor: 699
creators_name: Xu, Rui
creators_name: O'Reilly, Meaghan Anne
title: Array-Based Beamforming to the Vertebral Canal: Demonstration of Feasibility
ispublished: inpress
divisions: C05
divisions: F42
divisions: B04
divisions: UCL
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Focused ultrasound blood-spinal cord barrier opening is a promising new method for improving the non-invasive delivery of therapeutic agents to the spinal cord. A custom 64-element phased array was built, based on the design of a component of a spine-specific array for focusing ultrasound through vertebral laminae and correcting vertebra-induced distortions. Geometric and hydrophone delays were tested in each thoracic vertebra in an ex vivo spine (n=12). Pressure fields were measured in each canal to measure focal aberrations. Geometric delays produced foci shifted by 2.4±1.7 mm from the target, while hydrophone delays produced foci 1.3±1.1 mm from the target. Simulation showed good correlation with hydrophone delays and may be a viable non-invasive method for phase corrections. This work demonstrates the feasibility of transvertebral ultrasound beamforming with a phased-array.
date: 2021-11-15
date_type: published
publisher: IEEE
official_url: https://doi.org/10.1109/IUS52206.2021.9593839
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1912070
doi: 10.1109/IUS52206.2021.9593839
lyricists_name: Xu, Rui
lyricists_id: RXUBX72
actors_name: Xu, Rui
actors_id: RXUBX72
actors_role: owner
full_text_status: public
pres_type: paper
publication: IEEE International Ultrasonics Symposium, IUS
event_title: 2021 IEEE International Ultrasonics Symposium (IUS)
event_dates: 11 Sep 2021 - 16 Sep 2021
book_title: IEEE International Ultrasonics Symposium, IUS
citation:        Xu, Rui;    O'Reilly, Meaghan Anne;      (2021)    Array-Based Beamforming to the Vertebral Canal: Demonstration of Feasibility.                     In:  IEEE International Ultrasonics Symposium, IUS.    IEEE    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10143014/1/IEEE_IUS_Array_Based_Beamforming%20copy.pdf