eprintid: 10142692 rev_number: 17 eprint_status: archive userid: 699 dir: disk0/10/14/26/92 datestamp: 2022-02-02 12:17:04 lastmod: 2024-10-22 10:13:44 status_changed: 2023-01-10 15:37:43 type: article metadata_visibility: show sword_depositor: 699 creators_name: Shapey, Jonathan creators_name: Xie, Yijing creators_name: Nabavi, Elham creators_name: Ebner, Michael creators_name: Saeed, Shakeel R creators_name: Kitchen, Neil creators_name: Dorward, Neil creators_name: Grieve, Joan creators_name: McEvoy, Andrew W creators_name: Miserocchi, Anna creators_name: Grover, Patrick creators_name: Bradford, Robert creators_name: Lim, Yau-Mun creators_name: Ourselin, Sebastien creators_name: Brandner, Sebastian creators_name: Jaunmuktane, Zane creators_name: Vercauteren, Tom title: Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near-infrared window ispublished: pub subjects: UCH divisions: C07 divisions: D07 divisions: B02 divisions: UCL divisions: F84 keywords: Absorption, Brain, Brain tumour, Optical properties, Scattering, Spectrophotmeter note: © 2022 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: Neuro-oncology surgery would benefit from detailed intraoperative tissue characterisation provided by non-contact, contrast-agent-free, non-invasive optical imaging methods. In-depth knowledge of target tissue optical properties across a wide-wavelength spectrum could inform the design of optical imaging and computational methods to enable robust tissue analysis during surgery. We adapted a dual-beam integrating sphere to analyse small tissue samples and investigated ex vivo optical properties of five types of human brain tumour (meningioma, pituitary adenoma, schwannoma, low- and high-grade glioma) and nine different types of healthy brain tissue across a wavelength spectrum of 400 – 1800 nm. Fresh and frozen tissue samples were analysed. All tissue types demonstrated similar absorption spectra, but the reduced scattering coefficients of tumours show visible differences in the obtained optical spectrum compared to those of surrounding normal tissue. These results underline the potential of optical imaging technologies for intraoperative tissue characterisation. date: 2022-04 date_type: published publisher: Wiley official_url: https://doi.org/10.1002/jbio.202100072 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1916332 doi: 10.1002/jbio.202100072 medium: Print-Electronic lyricists_name: McEvoy, Andrew lyricists_name: Jaunmuktane, Zane lyricists_id: AWMCE45 lyricists_id: ZJAUN70 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Journal of Biophotonics volume: 15 number: 4 article_number: e202100072 event_location: Germany citation: Shapey, Jonathan; Xie, Yijing; Nabavi, Elham; Ebner, Michael; Saeed, Shakeel R; Kitchen, Neil; Dorward, Neil; ... Vercauteren, Tom; + view all <#> Shapey, Jonathan; Xie, Yijing; Nabavi, Elham; Ebner, Michael; Saeed, Shakeel R; Kitchen, Neil; Dorward, Neil; Grieve, Joan; McEvoy, Andrew W; Miserocchi, Anna; Grover, Patrick; Bradford, Robert; Lim, Yau-Mun; Ourselin, Sebastien; Brandner, Sebastian; Jaunmuktane, Zane; Vercauteren, Tom; - view fewer <#> (2022) Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near-infrared window. Journal of Biophotonics , 15 (4) , Article e202100072. 10.1002/jbio.202100072 <https://doi.org/10.1002/jbio.202100072>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10142692/7/McEvoy_Journal%20of%20Biophotonics%20-%202022%20-%20Shapey%20-%20Optical%20properties%20of%20human%20brain%20and%20tumour%20tissue%20%20An%20ex%20vivo%20study%20spanning.pdf