eprintid: 10141835
rev_number: 13
eprint_status: archive
userid: 608
dir: disk0/10/14/18/35
datestamp: 2022-01-13 14:28:38
lastmod: 2022-07-01 06:11:59
status_changed: 2022-01-13 14:28:38
type: article
metadata_visibility: show
creators_name: Wheeler, DC
title: Chlorthalidone in Advanced Chronic Kidney Disease - Have We Missed a Trick?
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G93
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: Control of hypertension is central to the management of chronic kidney disease, both to preserve residual kidney function and to reduce the associated high risk of cardiovascular events. International guidelines recently updated by the Kidney Disease: Improving Global Outcomes Organization recommend that patients with chronic kidney disease and hypertension be treated to reduce standardized office systolic blood pressure to less than 120 mm Hg, unless there are obvious reasons not to do so. This ambitious target is difficult to achieve with currently available antihypertensive medications, particularly in patients with more advanced chronic kidney disease (stages 4 and 5)
date: 2021-12-30
date_type: published
publisher: MASSACHUSETTS MEDICAL SOC
official_url: https://doi.org/10.1056/NEJMe2118149
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1914032
doi: 10.1056/NEJMe2118149
lyricists_name: Wheeler, David
lyricists_id: DWHEE12
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: New England Journal of Medicine
volume: 385
number: 27
pagerange: 2574-2575
pages: 2
issn: 1533-4406
citation:        Wheeler, DC;      (2021)    Chlorthalidone in Advanced Chronic Kidney Disease - Have We Missed a Trick?                   New England Journal of Medicine , 385  (27)   pp. 2574-2575.    10.1056/NEJMe2118149 <https://doi.org/10.1056/NEJMe2118149>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10141835/1/nejme2118149.pdf