eprintid: 10141835 rev_number: 13 eprint_status: archive userid: 608 dir: disk0/10/14/18/35 datestamp: 2022-01-13 14:28:38 lastmod: 2022-07-01 06:11:59 status_changed: 2022-01-13 14:28:38 type: article metadata_visibility: show creators_name: Wheeler, DC title: Chlorthalidone in Advanced Chronic Kidney Disease - Have We Missed a Trick? ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G93 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. abstract: Control of hypertension is central to the management of chronic kidney disease, both to preserve residual kidney function and to reduce the associated high risk of cardiovascular events. International guidelines recently updated by the Kidney Disease: Improving Global Outcomes Organization recommend that patients with chronic kidney disease and hypertension be treated to reduce standardized office systolic blood pressure to less than 120 mm Hg, unless there are obvious reasons not to do so. This ambitious target is difficult to achieve with currently available antihypertensive medications, particularly in patients with more advanced chronic kidney disease (stages 4 and 5) date: 2021-12-30 date_type: published publisher: MASSACHUSETTS MEDICAL SOC official_url: https://doi.org/10.1056/NEJMe2118149 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1914032 doi: 10.1056/NEJMe2118149 lyricists_name: Wheeler, David lyricists_id: DWHEE12 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: New England Journal of Medicine volume: 385 number: 27 pagerange: 2574-2575 pages: 2 issn: 1533-4406 citation: Wheeler, DC; (2021) Chlorthalidone in Advanced Chronic Kidney Disease - Have We Missed a Trick? New England Journal of Medicine , 385 (27) pp. 2574-2575. 10.1056/NEJMe2118149 <https://doi.org/10.1056/NEJMe2118149>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10141835/1/nejme2118149.pdf