eprintid: 10141682 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/14/16/82 datestamp: 2022-01-11 12:47:38 lastmod: 2022-01-12 00:10:21 status_changed: 2022-01-11 12:47:38 type: article metadata_visibility: show creators_name: Satish, P creators_name: Freeman, A creators_name: Kelly, D creators_name: Kirkham, A creators_name: Orczyk, C creators_name: Simpson, BS creators_name: Giganti, F creators_name: Whitaker, HC creators_name: Emberton, M creators_name: Norris, JM title: Relationship of prostate cancer topography and tumour conspicuity on multiparametric magnetic resonance imaging: a protocol for a systematic review and meta-analysis ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D19 divisions: G99 divisions: D16 note: This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. abstract: Introduction: Multiparametric magnetic resonance imaging (mpMRI) has improved the triage of men with suspected prostate cancer, through precision prebiopsy identification of clinically significant disease. While multiple important characteristics, including tumour grade and size have been shown to affect conspicuity on mpMRI, tumour location and association with mpMRI visibility is an underexplored facet of this field. Therefore, the objective of this systematic review and meta-analysis is to collate the extant evidence comparing MRI performance between different locations within the prostate in men with existing or suspected prostate cancer. This review will help clarify mechanisms that underpin whether a tumour is visible, and the prognostic implications of our findings. // Methods and analysis: The databases MEDLINE, PubMed, Embase and Cochrane will be systematically searched for relevant studies. Eligible studies will be full-text English-language articles that examine the effect of zonal location on mpMRI conspicuity. Two reviewers will perform study selection, data extraction and quality assessment. A third reviewer will be involved if consensus is not achieved. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines will inform the methodology and reporting of the review. Study bias will be assessed using a modified Newcastle-Ottawa scale. A thematic approach will be used to synthesise key location-based factors associated with mpMRI conspicuity. A meta-analysis will be conducted to form a pooled value of the sensitivity and specificity of mpMRI at different tumour locations. // Ethics and dissemination: Ethical approval is not required as it is a protocol for a systematic review. Findings will be disseminated through peer-reviewed publications and conference presentations. date: 2022-01-01 date_type: published publisher: BMJ official_url: http://dx.doi.org/10.1136/bmjopen-2021-050376 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1913180 doi: 10.1136/bmjopen-2021-050376 lyricists_name: Giganti, Francesco lyricists_name: Norris, Joseph lyricists_name: Simpson, Benjamin lyricists_id: FGIGA51 lyricists_id: JMNOR34 lyricists_id: BSSIM61 actors_name: Kalinowski, Damian actors_id: DKALI47 actors_role: owner full_text_status: public publication: BMJ Open volume: 12 number: 1 article_number: e050376 issn: 2044-6055 citation: Satish, P; Freeman, A; Kelly, D; Kirkham, A; Orczyk, C; Simpson, BS; Giganti, F; ... Norris, JM; + view all <#> Satish, P; Freeman, A; Kelly, D; Kirkham, A; Orczyk, C; Simpson, BS; Giganti, F; Whitaker, HC; Emberton, M; Norris, JM; - view fewer <#> (2022) Relationship of prostate cancer topography and tumour conspicuity on multiparametric magnetic resonance imaging: a protocol for a systematic review and meta-analysis. BMJ Open , 12 (1) , Article e050376. 10.1136/bmjopen-2021-050376 <https://doi.org/10.1136/bmjopen-2021-050376>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10141682/1/Norris_Relationship%20of%20prostate%20cancer%20topography%20and%20tumour%20conspicuity%20on%20multiparametric%20magnetic%20resonance%20imaging_VoR.pdf