eprintid: 10141437
rev_number: 12
eprint_status: archive
userid: 608
dir: disk0/10/14/14/37
datestamp: 2022-01-10 14:50:52
lastmod: 2022-01-10 14:50:52
status_changed: 2022-01-10 14:50:52
type: article
metadata_visibility: show
creators_name: Sakai, NS
creators_name: Bhagwanani, A
creators_name: Bray, TJP
creators_name: Hall-Craggs, MA
creators_name: Taylor, SA
title: Assessment of body composition and association with clinical outcomes in patients with lung and colorectal cancer
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: FI6
note: © 2021 The Authors. Published by the British Institute of Radiology. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source
are credited.
abstract: OBJECTIVES: 
To assess body composition in patients with non-small cell lung cancer (NSCLC) and colorectal cancer using whole-body MRI and relate this to clinical outcomes.

METHODS: 
53 patients with NSCLC (28 males, 25 females; mean age 66.9) and 74 patients with colorectal cancer (42 males, 32 females; mean age 62.9) underwent staging whole-body MRI scans, which were post-processed to derive fat mass (FM), fat free mass (FFM) and skeletal muscle (SM) indices and SM fat fraction (FF). These were compared between the two cancer cohorts using two-sided t-tests and the chi-squared test. Measurements of body composition were correlated with outcomes including length of hospital stay, metastatic status and mortality.

RESULTS: 
Patients with NSCLC had significantly lower FFM (p = 0.0071) and SM (p = 0.0084) indices. Mean SM FF was greater in patients with NSCLC (p = 0.0124) and was associated with longer hospital stay (p = 0.035). There was no significant relationship between FM, FFM and SM indices and length of hospital stay, metastatic status or mortality.

CONCLUSIONS: 
Patients with NSCLC had lower FFM and SM indices than patients with colorectal cancer and greater SMFF, indicating lower SM mass with fatty infiltration. These findings reflect differences in the phenotype of the two groups and suggest patients with lung cancer are more likely to require additional nutritional support.

ADVANCES IN KNOWLEDGE: 
Body composition differs between NSCLC and colorectal cancer. Patients with NSCLC have both a reduced SM mass and greater SM FF suggesting that they are more nutritionally deplete than patients with colorectal cancer.
date: 2021-01-01
date_type: published
publisher: British Institute of Radiology
official_url: https://doi.org/10.1259/bjro.20210048
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1913184
doi: 10.1259/bjro.20210048
lyricists_name: Bray, Timothy
lyricists_id: TBRAY81
actors_name: Bray, Timothy
actors_id: TBRAY81
actors_role: owner
full_text_status: public
publication: BJR|Open
volume: 3
number: 1
citation:        Sakai, NS;    Bhagwanani, A;    Bray, TJP;    Hall-Craggs, MA;    Taylor, SA;      (2021)    Assessment of body composition and association with clinical outcomes in patients with lung and colorectal cancer.                   BJR|Open , 3  (1)      10.1259/bjro.20210048 <https://doi.org/10.1259/bjro.20210048>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10141437/1/bjro.20210048.pdf