eprintid: 10141334
rev_number: 17
eprint_status: archive
userid: 608
dir: disk0/10/14/13/34
datestamp: 2022-01-06 15:02:21
lastmod: 2023-01-20 07:10:22
status_changed: 2022-01-06 15:02:21
type: article
metadata_visibility: show
creators_name: Howarth, C
creators_name: Leung, T
creators_name: Banerjee, J
creators_name: Eaton, S
creators_name: Morris, J
creators_name: Aladangady, N
title: Regional cerebral and splanchnic tissue oxygen saturation in preterm infants – longitudinal normative measurements
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
divisions: B04
divisions: C05
divisions: F42
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: 
To investigate regional splanchnic and cerebral tissue oxygen saturation in preterm infants <30 weeks gestation.

METHODS: 
Cerebral (cTOI) and splanchnic (sTOI) Tissue Oxygenation Index were measured weekly in 5 min epochs for a total period of 60 min using NIRS (NIRO-300) for the first 8 weeks of life, in 48 appropriately grown preterm infants born at <30 weeks gestation. Infants who developed HPI and/or NEC (n = 12) and those that died (n = 1) were excluded from our main outcome measure of regional gut and cerebral tissue oxygenation in healthy preterm infants <30 weeks gestation.

RESULTS: 
Median birthweight 789 g (460–1486), gestational age 25+6 weeks (23+0–29+1) and 51.4% female. 217 NIRS measurements were completed across the first 8 weeks of life. Mean weekly cTOI ranged from 56.8–65.4% and sTOI ranged from 36.7–46.0%. Mean cTOI was significantly higher than mean sTOI (p < 0.001) throughout the first 8 weeks of life. Mean cTOI decreased significantly with increasing postnatal age [−0.59% each week (−1.26% to −0.07%) p = 0.04]. None of the examined confounding factors had a significant effect.

CONCLUSIONS: 
This is the first report of regional cerebral and splanchnic tissue oxygen saturation ranges during the first 8 weeks of life for preterm infants born at <30 weeks gestation.
date: 2022-02
date_type: published
publisher: Elsevier
official_url: https://doi.org/10.1016/j.earlhumdev.2022.105540
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1913103
doi: 10.1016/j.earlhumdev.2022.105540
lyricists_name: Eaton, Simon
lyricists_name: Leung, Terence
lyricists_id: SEATO65
lyricists_id: TSTLE21
actors_name: Eaton, Simon
actors_id: SEATO65
actors_role: owner
full_text_status: public
publication: Early Human Development
volume: 165
article_number: 105540
citation:        Howarth, C;    Leung, T;    Banerjee, J;    Eaton, S;    Morris, J;    Aladangady, N;      (2022)    Regional cerebral and splanchnic tissue oxygen saturation in preterm infants – longitudinal normative measurements.                   Early Human Development , 165     , Article 105540.  10.1016/j.earlhumdev.2022.105540 <https://doi.org/10.1016/j.earlhumdev.2022.105540>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10141334/1/NIRS%20normal%20distribution%20article_EHD_accepted.pdf