eprintid: 10139982 rev_number: 15 eprint_status: archive userid: 608 dir: disk0/10/13/99/82 datestamp: 2021-12-09 21:06:45 lastmod: 2022-11-18 15:17:38 status_changed: 2021-12-09 21:06:45 type: article metadata_visibility: show creators_name: Brieger, KK creators_name: Phung, MT creators_name: Mukherjee, B creators_name: Bakulski, KM creators_name: Anton-Culver, H creators_name: Bandera, EV creators_name: Bowtell, DDL creators_name: Cramer, DW creators_name: DeFazio, A creators_name: Doherty, JA creators_name: Fereday, S creators_name: Fortner, RT creators_name: Gentry-Maharaj, A creators_name: Goode, EL creators_name: Goodman, MT creators_name: Harris, HR creators_name: Matsuo, K creators_name: Menon, U creators_name: Modugno, F creators_name: Moysich, KB creators_name: Qin, B creators_name: Ramus, SJ creators_name: Risch, HA creators_name: Rossing, MA creators_name: Schildkraut, JM creators_name: Trabert, B creators_name: Vierkant, RA creators_name: Winham, SJ creators_name: Wentzensen, N creators_name: Wu, AH creators_name: Ziogas, A creators_name: Khoja, L creators_name: Cho, KR creators_name: McLean, K creators_name: Richardson, J creators_name: Grout, B creators_name: Chase, A creators_name: McKinnon Deurloo, C creators_name: Odunsi, K creators_name: Nelson, BH creators_name: Brenton, JD creators_name: Terry, KL creators_name: Pharaoh, PD creators_name: Berchuck, A creators_name: Hanley, GE creators_name: Webb, PM creators_name: Pike, MC creators_name: Pearce, CL title: High pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival ispublished: pub divisions: UCL divisions: B02 divisions: D65 divisions: J38 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: BACKGROUND: There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined effects. METHODS: This analysis used pooled data on 8,147 women with invasive epithelial ovarian cancer from the Ovarian Cancer Association Consortium. Pre-diagnosis inflammatory-related exposures of interest included alcohol use, aspirin use, other nonsteroidal anti-inflammatory drug use, body mass index, environmental tobacco smoke exposure, history of pelvic inflammatory disease, polycystic ovarian syndrome, and endometriosis, menopausal hormone therapy use, physical inactivity, smoking status, and talc use. Using Cox proportional hazards (PH) models, the relationship between each exposure and survival was assessed in 50% of the data. A weighted inflammation-related risk score (IRRS) was developed and its association with survival was assessed using Cox PH models in the remaining 50% of the data. RESULTS: There was a statistically significant trend of increasing risk of death per quartile of the IRRS (HR=1.09, 95% CI 1.03-1.14). Women in the upper quartile of the IRRS had 31% higher death rate compared to the lowest quartile (95% CI 1.11-1.54). CONCLUSIONS: A higher pre-diagnosis IRRS was associated with increased mortality risk after an ovarian cancer diagnosis. Further investigation is warranted to evaluate whether post-diagnosis exposures are also associated with survival. IMPACT: Given that pre- and post-diagnosis exposures are often correlated and many are modifiable, our study results can ultimately motivate the development of behavioral recommendations to enhance survival among ovarian cancer patients. date: 2022-02-01 date_type: published official_url: https://doi.org/10.1158/1055-9965.EPI-21-0977 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1906062 doi: 10.1158/1055-9965.EPI-21-0977 pii: 1055-9965.EPI-21-0977 lyricists_name: Gentry-Maharaj, Aleksandra lyricists_name: Menon, Usha lyricists_id: AGENT07 lyricists_id: UMENO29 actors_name: Menon, Usha actors_name: Widdup, Anna actors_id: UMENO29 actors_id: AWIDD73 actors_role: owner actors_role: impersonator full_text_status: public publication: Cancer Epidemiology, Biomarkers and Prevention volume: 31 number: 2 pagerange: 443-452 event_location: United States citation: Brieger, KK; Phung, MT; Mukherjee, B; Bakulski, KM; Anton-Culver, H; Bandera, EV; Bowtell, DDL; ... Pearce, CL; + view all <#> Brieger, KK; Phung, MT; Mukherjee, B; Bakulski, KM; Anton-Culver, H; Bandera, EV; Bowtell, DDL; Cramer, DW; DeFazio, A; Doherty, JA; Fereday, S; Fortner, RT; Gentry-Maharaj, A; Goode, EL; Goodman, MT; Harris, HR; Matsuo, K; Menon, U; Modugno, F; Moysich, KB; Qin, B; Ramus, SJ; Risch, HA; Rossing, MA; Schildkraut, JM; Trabert, B; Vierkant, RA; Winham, SJ; Wentzensen, N; Wu, AH; Ziogas, A; Khoja, L; Cho, KR; McLean, K; Richardson, J; Grout, B; Chase, A; McKinnon Deurloo, C; Odunsi, K; Nelson, BH; Brenton, JD; Terry, KL; Pharaoh, PD; Berchuck, A; Hanley, GE; Webb, PM; Pike, MC; Pearce, CL; - view fewer <#> (2022) High pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival. Cancer Epidemiology, Biomarkers and Prevention , 31 (2) pp. 443-452. 10.1158/1055-9965.EPI-21-0977 <https://doi.org/10.1158/1055-9965.EPI-21-0977>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10139982/1/Brieger%202021%20inflammation.pdf