eprintid: 10139982
rev_number: 15
eprint_status: archive
userid: 608
dir: disk0/10/13/99/82
datestamp: 2021-12-09 21:06:45
lastmod: 2022-11-18 15:17:38
status_changed: 2021-12-09 21:06:45
type: article
metadata_visibility: show
creators_name: Brieger, KK
creators_name: Phung, MT
creators_name: Mukherjee, B
creators_name: Bakulski, KM
creators_name: Anton-Culver, H
creators_name: Bandera, EV
creators_name: Bowtell, DDL
creators_name: Cramer, DW
creators_name: DeFazio, A
creators_name: Doherty, JA
creators_name: Fereday, S
creators_name: Fortner, RT
creators_name: Gentry-Maharaj, A
creators_name: Goode, EL
creators_name: Goodman, MT
creators_name: Harris, HR
creators_name: Matsuo, K
creators_name: Menon, U
creators_name: Modugno, F
creators_name: Moysich, KB
creators_name: Qin, B
creators_name: Ramus, SJ
creators_name: Risch, HA
creators_name: Rossing, MA
creators_name: Schildkraut, JM
creators_name: Trabert, B
creators_name: Vierkant, RA
creators_name: Winham, SJ
creators_name: Wentzensen, N
creators_name: Wu, AH
creators_name: Ziogas, A
creators_name: Khoja, L
creators_name: Cho, KR
creators_name: McLean, K
creators_name: Richardson, J
creators_name: Grout, B
creators_name: Chase, A
creators_name: McKinnon Deurloo, C
creators_name: Odunsi, K
creators_name: Nelson, BH
creators_name: Brenton, JD
creators_name: Terry, KL
creators_name: Pharaoh, PD
creators_name: Berchuck, A
creators_name: Hanley, GE
creators_name: Webb, PM
creators_name: Pike, MC
creators_name: Pearce, CL
title: High pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival
ispublished: pub
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: 
There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined effects. 

METHODS: 
This analysis used pooled data on 8,147 women with invasive epithelial ovarian cancer from the Ovarian Cancer Association Consortium. Pre-diagnosis inflammatory-related exposures of interest included alcohol use, aspirin use, other nonsteroidal anti-inflammatory drug use, body mass index, environmental tobacco smoke exposure, history of pelvic inflammatory disease, polycystic ovarian syndrome, and endometriosis, menopausal hormone therapy use, physical inactivity, smoking status, and talc use. Using Cox proportional hazards (PH) models, the relationship between each exposure and survival was assessed in 50% of the data. A weighted inflammation-related risk score (IRRS) was developed and its association with survival was assessed using Cox PH models in the remaining 50% of the data. 

RESULTS: 
There was a statistically significant trend of increasing risk of death per quartile of the IRRS (HR=1.09, 95% CI 1.03-1.14). Women in the upper quartile of the IRRS had 31% higher death rate compared to the lowest quartile (95% CI 1.11-1.54). 


CONCLUSIONS: 
A higher pre-diagnosis IRRS was associated with increased mortality risk after an ovarian cancer diagnosis. Further investigation is warranted to evaluate whether post-diagnosis exposures are also associated with survival. 

IMPACT: 
Given that pre- and post-diagnosis exposures are often correlated and many are modifiable, our study results can ultimately motivate the development of behavioral recommendations to enhance survival among ovarian cancer patients.
date: 2022-02-01
date_type: published
official_url: https://doi.org/10.1158/1055-9965.EPI-21-0977
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1906062
doi: 10.1158/1055-9965.EPI-21-0977
pii: 1055-9965.EPI-21-0977
lyricists_name: Gentry-Maharaj, Aleksandra
lyricists_name: Menon, Usha
lyricists_id: AGENT07
lyricists_id: UMENO29
actors_name: Menon, Usha
actors_name: Widdup, Anna
actors_id: UMENO29
actors_id: AWIDD73
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Cancer Epidemiology, Biomarkers and Prevention
volume: 31
number: 2
pagerange: 443-452
event_location: United States
citation:        Brieger, KK;    Phung, MT;    Mukherjee, B;    Bakulski, KM;    Anton-Culver, H;    Bandera, EV;    Bowtell, DDL;                                                                                                                                                                     ... Pearce, CL; + view all <#>        Brieger, KK;  Phung, MT;  Mukherjee, B;  Bakulski, KM;  Anton-Culver, H;  Bandera, EV;  Bowtell, DDL;  Cramer, DW;  DeFazio, A;  Doherty, JA;  Fereday, S;  Fortner, RT;  Gentry-Maharaj, A;  Goode, EL;  Goodman, MT;  Harris, HR;  Matsuo, K;  Menon, U;  Modugno, F;  Moysich, KB;  Qin, B;  Ramus, SJ;  Risch, HA;  Rossing, MA;  Schildkraut, JM;  Trabert, B;  Vierkant, RA;  Winham, SJ;  Wentzensen, N;  Wu, AH;  Ziogas, A;  Khoja, L;  Cho, KR;  McLean, K;  Richardson, J;  Grout, B;  Chase, A;  McKinnon Deurloo, C;  Odunsi, K;  Nelson, BH;  Brenton, JD;  Terry, KL;  Pharaoh, PD;  Berchuck, A;  Hanley, GE;  Webb, PM;  Pike, MC;  Pearce, CL;   - view fewer <#>    (2022)    High pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival.                   Cancer Epidemiology, Biomarkers and Prevention , 31  (2)   pp. 443-452.    10.1158/1055-9965.EPI-21-0977 <https://doi.org/10.1158/1055-9965.EPI-21-0977>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10139982/1/Brieger%202021%20inflammation.pdf