eprintid: 10138674
rev_number: 12
eprint_status: archive
userid: 608
dir: disk0/10/13/86/74
datestamp: 2021-11-19 11:00:57
lastmod: 2021-11-19 11:00:57
status_changed: 2021-11-19 11:00:57
type: article
metadata_visibility: show
creators_name: Drobnjak, I
creators_name: Neher, P
creators_name: Poupon, C
creators_name: Sarwar, T
title: Physical and digital phantoms for validating tractography and assessing artifacts
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F48
note: © 2021 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
abstract: Fiber tractography is widely used to non-invasively map white-matter bundles in vivo using diffusion-weighted magnetic resonance imaging (dMRI). As it is the case for all scientific methods, proper validation is a key prerequisite for the successful application of fiber tractography, be it in the area of basic neuroscience or in a clinical setting. It is well-known that the indirect estimation of the fiber tracts from the local diffusion signal is highly ambiguous and extremely challenging. Furthermore, the validation of fiber tractography methods is hampered by the lack of a real ground truth, which is caused by the extremely complex brain microstructure that is not directly observable non-invasively and that is the basis of the huge network of long-range fiber connections in the brain that are the actual target of fiber tractography methods. As a substitute for in vivo data with a real ground truth that could be used for validation, a widely and successfully employed approach is the use of synthetic phantoms. In this work, we are providing an overview of the state-of-the-art in the area of physical and digital phantoms, answering the following guiding questions: “What are dMRI phantoms and what are they good for?”, “What would the ideal phantom for validation fiber tractography look like?” and “What phantoms, phantom datasets and tools used for their creation are available to the research community?”. We will further discuss the limitations and opportunities that come with the use of dMRI phantoms, and what future direction this field of research might take.
date: 2021-12-15
date_type: published
official_url: https://doi.org/10.1016/j.neuroimage.2021.118704
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1901189
doi: 10.1016/j.neuroimage.2021.118704
pii: S1053-8119(21)00976-9
lyricists_name: Drobnjak, Ivana
lyricists_id: IDROB84
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Neuroimage
volume: 245
article_number: 118704
event_location: United States
issn: 1095-9572
citation:        Drobnjak, I;    Neher, P;    Poupon, C;    Sarwar, T;      (2021)    Physical and digital phantoms for validating tractography and assessing artifacts.                   Neuroimage , 245     , Article 118704.  10.1016/j.neuroimage.2021.118704 <https://doi.org/10.1016/j.neuroimage.2021.118704>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10138674/1/1-s2.0-S1053811921009769-main.pdf