eprintid: 10137989
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/13/79/89
datestamp: 2021-11-10 10:59:04
lastmod: 2022-10-12 14:28:29
status_changed: 2021-11-10 10:59:04
type: article
metadata_visibility: show
creators_name: Jones, TPW
creators_name: Lampe, FC
creators_name: Arenas-Pinto, A
creators_name: Smith, C
creators_name: McDonnell, J
creators_name: Haddow, L
creators_name: Johnson, M
creators_name: Yousef, E
creators_name: Lascar, M
creators_name: Maria Geretti, A
creators_name: Sherr, L
creators_name: Collins, S
creators_name: Phillips, AN
creators_name: Rodger, AJ
title: Alcohol, smoking, recreational drug use and association with virological outcomes among people living with HIV: cross-sectional and longitudinal analyses
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D05
divisions: F66
divisions: D01
divisions: G16
keywords: adherence, alcohol dependence, viral non-suppression, recreational drugs, smoking
note: Copyright © 2021 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: Objectives:
There is increasing evidence to suggest that people living with HIV (PLWH) have significant morbidity from alcohol, recreational drug use and cigarette smoking. Our aim was to report associations of these factors with antiretroviral therapy (ART) non-adherence, viral non-suppression and subsequent viral rebound in PLWH. /

Methods:
The Antiretroviral Sexual Transmission Risk and Attitudes (ASTRA) study recruited PLWH attending eight outpatient clinics in England between February 2011 and December 2012. Data included self-reported excessive drinking (estimated consumption of > 20 units of alcohol/week), alcohol dependency (CAGE score ≥ 2 with current alcohol consumption), recreational drug use (including injection drug use in the past 3 months), and smoking status. Among participants established on ART, cross-sectional associations with ART non-adherence [missing ≥2 consecutive days of ART on ≥2 occasions in the past three months] and viral-non suppression [viral load (VL) > 50 copies/mL] were assessed using logistic regression. In participants from one centre, longitudinal associations with subsequent viral rebound (first VL > 200 copies/mL) in those on ART with VL ≤ 50 copies/mL at baseline were assessed using Cox regression during a 7-year follow-up. /

Results:
Among 3258 PLWH, 2248 (69.0%) were men who have sex with men, 373 (11.4%) were heterosexual men, and 637 (19.6%) were women. A CAGE score ≥ 2 was found in 568 (17.6%) participants, 325 (10.1%) drank > 20 units/week, 1011 (31.5%) currently smoked, 1242 (38.1%) used recreational drugs and 74 (2.3%) reported injection drug use. In each case, prevalence was much more common among men than among women. Among 2459 people on ART who started at least 6 months previously, a CAGE score ≥ 2, drinking > 20 units per week, current smoking, injection and non-injection drug use were all associated with ART non-adherence. After adjusting for demographic and socioeconomic factors, CAGE score ≥ 2 [adjusted odds ratio (aOR) = 1.52, 95% confidence interval (CI): 1.09–2.13], current smoking (aOR = 1.58, 95% CI: 1.10–2.17) and injection drug use (aOR = 2.11, 95% CI: 1.00–4.47) were associated with viral non-suppression. During follow-up of a subset of 592 people virally suppressed at recruitment, a CAGE score ≥ 2 [adjusted hazard ratio (aHR) = 1.66, 95% CI: 1.03–2.74], use of 3 or more non-injection drugs (aHR = 1.82, 95% CI: 1.12–3.57) and injection drug use (aHR = 2.73, 95% CI: 1.08–6.89) were associated with viral rebound. /

Conclusions:
Screening and treatment for alcohol, cigarette and drug use should be integrated into HIV outpatient clinics, while clinicians should be alert to the potential for poorer virological outcomes.
date: 2022-03
date_type: published
publisher: WILEY
official_url: https://doi.org/10.1111/hiv.13156
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1893715
doi: 10.1111/hiv.13156
lyricists_name: Arenas-Pinto, Alejandro
lyricists_name: Lampe, Fiona
lyricists_name: McDonnell, Jeffrey
lyricists_name: Phillips, Andrew
lyricists_name: Rodger, Alison
lyricists_name: Sherr, Lorraine
lyricists_name: Smith, Colette
lyricists_id: AAREN61
lyricists_id: FLAMP12
lyricists_id: JMCDO27
lyricists_id: APHIL63
lyricists_id: ARODG08
lyricists_id: LSHER47
lyricists_id: CJSMI83
actors_name: Jayawardana, Anusha
actors_id: AJAYA51
actors_role: owner
full_text_status: public
publication: HIV Medicine
volume: 23
number: 3
pagerange: 209-226
pages: 18
issn: 1468-1293
citation:        Jones, TPW;    Lampe, FC;    Arenas-Pinto, A;    Smith, C;    McDonnell, J;    Haddow, L;    Johnson, M;                             ... Rodger, AJ; + view all <#>        Jones, TPW;  Lampe, FC;  Arenas-Pinto, A;  Smith, C;  McDonnell, J;  Haddow, L;  Johnson, M;  Yousef, E;  Lascar, M;  Maria Geretti, A;  Sherr, L;  Collins, S;  Phillips, AN;  Rodger, AJ;   - view fewer <#>    (2022)    Alcohol, smoking, recreational drug use and association with virological outcomes among people living with HIV: cross-sectional and longitudinal analyses.                   HIV Medicine , 23  (3)   pp. 209-226.    10.1111/hiv.13156 <https://doi.org/10.1111/hiv.13156>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10137989/8/Rodger_HIV%20Medicine%20-%202021%20-%20Jones%20-%20Alcohol%20%20smoking%20%20recreational%20drug%20use%20and%20association%20with%20virological%20outcomes%20among.pdf