eprintid: 10137866
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/13/78/66
datestamp: 2021-11-09 13:42:31
lastmod: 2021-12-10 01:06:49
status_changed: 2021-11-09 13:42:31
type: article
metadata_visibility: show
creators_name: Ward, TH
creators_name: Gilbert, DC
creators_name: Higginbotham, G
creators_name: Morris, CM
creators_name: Speirs, V
creators_name: Curtin, NJ
title: Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations
ispublished: inpress
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
keywords: biobanking, radiotherapy
note: © 2021 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long-term disease control/cure. There are significant inter-patient differences in response, both in terms of efficacy and toxicity (frequently delayed onset) which are difficult to predict. With the introduction of technological improvements (e.g. stereotactic body radiotherapy and proton therapy) and development of combination therapies (e.g. radiotherapy and immune checkpoint inhibition), predictive biomarkers are needed even more. Whilst genomic studies have contributed significantly to predictions of response to anticancer therapy, there is no doubt that more information can be gathered from patient tissue samples. Patients are willing to donate their tissues to biobanks and wish them to be used as widely as possible for high-quality research. We report here a survey of the current practices in the UK from several groups collecting material from patients in radiotherapy trials and have identified barriers to collecting and sharing data and samples. We believe the current situation represents a significant missed opportunity to improve the personalisation of radiotherapy. We propose a greater involvement of patients and/or their advocates, a standardisation of the patient information leaflet, consent form content and data set, with easy linkage to clinical data, which would facilitate widespread sample and data discovery and availability to other researchers. The greater sharing of data and samples, nationally and internationally, would facilitate robust multicentre studies and avoid duplication of effort.
date: 2021-10-17
date_type: published
official_url: https://doi.org/10.1002/cjp2.246
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1897344
doi: 10.1002/cjp2.246
lyricists_name: Gilbert, Duncan
lyricists_id: DGILB61
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Journal of Pathology: Clinical Research
event_location: England
citation:        Ward, TH;    Gilbert, DC;    Higginbotham, G;    Morris, CM;    Speirs, V;    Curtin, NJ;      (2021)    Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations.                   Journal of Pathology: Clinical Research        10.1002/cjp2.246 <https://doi.org/10.1002/cjp2.246>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10137866/1/cjp2.246.pdf