eprintid: 10136671
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/13/66/71
datestamp: 2021-10-20 09:46:17
lastmod: 2022-09-01 14:43:59
status_changed: 2021-10-20 09:46:17
type: article
metadata_visibility: show
creators_name: Giani, T
creators_name: Smith, EM
creators_name: Al-Abadi, E
creators_name: Armon, K
creators_name: Bailey, K
creators_name: Ciurtin, C
creators_name: Davidson, J
creators_name: Gardner-Medwin, J
creators_name: Haslam, K
creators_name: Hawley, DP
creators_name: Leahy, A
creators_name: Leone, V
creators_name: McErlane, F
creators_name: Mewar, D
creators_name: Modgil, G
creators_name: Moots, R
creators_name: Pilkington, C
creators_name: Pregnolato, F
creators_name: Ramanan, AV
creators_name: Rangaraj, S
creators_name: Riley, P
creators_name: Sridhar, A
creators_name: Wilkinson, N
creators_name: Cimaz, R
creators_name: Beresford, MW
creators_name: Hedrich, CM
creators_name: UK JSLE Cohort Study, .
title: Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study
ispublished: inpress
subjects: GOSH
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G90
keywords: Systemic lupus erythematosus, central nervous system, juvenile, neuropsychiatric, pediatric, peripheral nervous system
note: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
abstract: Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous range of neurological and psychiatric manifestations. // Methods: Demographic, clinical, and laboratory features of NP-SLE were assessed in participants of the UK JSLE Cohort Study, and compared to patients in the same cohort without NP manifestations. // Results: A total of 428 JSLE patients were included in this study, 25% of which exhibited NP features, half of them at first visit. Most common neurological symptoms among NP-JSLE patients included headaches (78.5%), mood disorders (48.6%), cognitive impairment (42%), anxiety (23.3%), seizures (19.6%), movement disorders (17.7%), and cerebrovascular disease (14.9%). Peripheral nervous system involvement was recorded in 7% of NP-SLE patients. NP-JSLE patients more frequently exhibited thrombocytopenia (<100 × 109/L) (p = 0.04), higher C-reactive protein levels (p = 0.01), higher global pBILAG score at first visit (p < 0.001), and higher SLICC damage index score at first (p = 0.02) and last (p < 0.001) visit when compared to JSLE patients without NP involvement. // Conclusions: A significant proportion of JSLE patients experience NP involvement (25%). Juvenile-onset NP-SLE most commonly affects the CNS and is associated with increased overall disease activity and damage.
date: 2021-10-02
date_type: published
official_url: https://doi.org/10.1177/09612033211045050
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1893705
doi: 10.1177/09612033211045050
lyricists_name: Ciurtin, Coziana
lyricists_id: CCIUR23
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: Lupus
event_location: England
citation:        Giani, T;    Smith, EM;    Al-Abadi, E;    Armon, K;    Bailey, K;    Ciurtin, C;    Davidson, J;                                                                                 ... UK JSLE Cohort Study, .; + view all <#>        Giani, T;  Smith, EM;  Al-Abadi, E;  Armon, K;  Bailey, K;  Ciurtin, C;  Davidson, J;  Gardner-Medwin, J;  Haslam, K;  Hawley, DP;  Leahy, A;  Leone, V;  McErlane, F;  Mewar, D;  Modgil, G;  Moots, R;  Pilkington, C;  Pregnolato, F;  Ramanan, AV;  Rangaraj, S;  Riley, P;  Sridhar, A;  Wilkinson, N;  Cimaz, R;  Beresford, MW;  Hedrich, CM;  UK JSLE Cohort Study, .;   - view fewer <#>    (2021)    Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study.                   Lupus        10.1177/09612033211045050 <https://doi.org/10.1177/09612033211045050>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10136671/1/Ciurtin_Neuropsychiatric%20involvement%20in%20juvenile-onset%20systemic%20lupus%20erythematosus_AOP.pdf