TY  - INPR
UR  - https://doi.org/10.1177/09612033211045050
ID  - discovery10136671
N2  - Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous range of neurological and psychiatric manifestations. // Methods: Demographic, clinical, and laboratory features of NP-SLE were assessed in participants of the UK JSLE Cohort Study, and compared to patients in the same cohort without NP manifestations. // Results: A total of 428 JSLE patients were included in this study, 25% of which exhibited NP features, half of them at first visit. Most common neurological symptoms among NP-JSLE patients included headaches (78.5%), mood disorders (48.6%), cognitive impairment (42%), anxiety (23.3%), seizures (19.6%), movement disorders (17.7%), and cerebrovascular disease (14.9%). Peripheral nervous system involvement was recorded in 7% of NP-SLE patients. NP-JSLE patients more frequently exhibited thrombocytopenia (<100 × 109/L) (p = 0.04), higher C-reactive protein levels (p = 0.01), higher global pBILAG score at first visit (p < 0.001), and higher SLICC damage index score at first (p = 0.02) and last (p < 0.001) visit when compared to JSLE patients without NP involvement. // Conclusions: A significant proportion of JSLE patients experience NP involvement (25%). Juvenile-onset NP-SLE most commonly affects the CNS and is associated with increased overall disease activity and damage.
KW  - Systemic lupus erythematosus
KW  -  central nervous system
KW  -  juvenile
KW  -  neuropsychiatric
KW  -  pediatric
KW  -  peripheral nervous system
A1  - Giani, T
A1  - Smith, EM
A1  - Al-Abadi, E
A1  - Armon, K
A1  - Bailey, K
A1  - Ciurtin, C
A1  - Davidson, J
A1  - Gardner-Medwin, J
A1  - Haslam, K
A1  - Hawley, DP
A1  - Leahy, A
A1  - Leone, V
A1  - McErlane, F
A1  - Mewar, D
A1  - Modgil, G
A1  - Moots, R
A1  - Pilkington, C
A1  - Pregnolato, F
A1  - Ramanan, AV
A1  - Rangaraj, S
A1  - Riley, P
A1  - Sridhar, A
A1  - Wilkinson, N
A1  - Cimaz, R
A1  - Beresford, MW
A1  - Hedrich, CM
A1  - UK JSLE Cohort Study, .
JF  - Lupus
Y1  - 2021/10/02/
AV  - public
TI  - Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study
N1  - This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
ER  -