eprintid: 10136642
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/13/66/42
datestamp: 2021-10-20 11:04:33
lastmod: 2022-08-26 06:11:17
status_changed: 2021-10-20 11:04:33
type: article
metadata_visibility: show
creators_name: Cheng, SF
creators_name: Richards, T
creators_name: Gregson, J
creators_name: Brown, MM
creators_name: de Borst, GJ
creators_name: Bonati, LH
creators_name: International Carotid Stenting Study investigators, .
title: Long Term Restenosis Rate After Carotid Endarterectomy: Comparison of Three Surgical Techniques and Intra-Operative Shunt Use
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F82
divisions: D65
divisions: J38
keywords: Carotid endarterectomy, Carotid stenosis, Restenosis, Stroke
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: OBJECTIVE: Closure of the artery during carotid endarterectomy (CEA) can be done with or without a patch, or performed with the eversion technique, while the use of intra-operative shunts is optional. The influence of these techniques on subsequent restenosis is uncertain. Long term carotid restenosis rates and risk of future ipsilateral stroke with these techniques were compared. METHODS: Patients who underwent CEA in the International Carotid Stenting Study were divided into patch angioplasty, primary closure, or eversion endarterectomy. Intra-operative shunt use was reported. Carotid duplex ultrasound was performed at each follow up. Primary outcomes were restenosis of ≥ 50% and ≥ 70%, and ipsilateral stroke after the procedure to the end of follow up. RESULTS: In total, 790 CEA patients had restenosis data at one and five years. Altogether, 511 (64.7%) had patch angioplasty, 232 (29.4%) primary closure, and 47 (5.9%) eversion endarterectomy. The cumulative incidence of ≥ 50% restenosis at one year was 18.9%, 26.1%, and 17.7%, respectively, and at five years it was 25.9%, 37.2%, and 30.0%, respectively. There was no difference in risk between the eversion and patch angioplasty group (hazard ratio [HR] 0.90, 95% confidence interval [CI] 0.45 - 1.81; p = .77). Primary closure had a higher risk of restenosis than patch angioplasty (HR 1.45, 95% CI 1.06 - 1.98; p = .019). The cumulative incidence of ≥ 70% restenosis did not differ between primary closure and patch angioplasty (12.1% vs. 7.1%, HR 1.59, 95% CI 0.88 - 2.89; p = .12) or between patch angioplasty and eversion endarterectomy (4.7%, HR 0.45, 95% CI 0.06 - 3.35; p = .44). There was no effect of shunt use on the cumulative incidence of restenosis. Post-procedural ipsilateral stroke was not more common in either of the surgical techniques or shunt use. CONCLUSION: Restenosis was more common after primary closure than conventionally with a patch closure. Shunt use had no effect on restenosis. Patch closure is the treatment of choice to avoid restenosis.
date: 2021-10
date_type: published
official_url: https://doi.org/10.1016/j.ejvs.2021.06.028
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1887470
doi: 10.1016/j.ejvs.2021.06.028
pii: S1078-5884(21)00534-7
lyricists_name: Brown, Martin
lyricists_name: Cheng, Suk Fun
lyricists_name: Richards, Toby
lyricists_id: MMBRO52
lyricists_id: SFCHE27
lyricists_id: TRICH60
actors_name: Brown, Martin
actors_id: MMBRO52
actors_role: owner
full_text_status: public
publication: European Journal of Vascular and Endovascular Surgery
volume: 62
number: 4
pagerange: 513-521
event_location: England
citation:        Cheng, SF;    Richards, T;    Gregson, J;    Brown, MM;    de Borst, GJ;    Bonati, LH;    International Carotid Stenting Study investigators, .;      (2021)    Long Term Restenosis Rate After Carotid Endarterectomy: Comparison of Three Surgical Techniques and Intra-Operative Shunt Use.                   European Journal of Vascular and Endovascular Surgery , 62  (4)   pp. 513-521.    10.1016/j.ejvs.2021.06.028 <https://doi.org/10.1016/j.ejvs.2021.06.028>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10136642/3/Brown_Long%20Term%20Restenosis%20Rate%20After%20Carotid%20Endarterectomy-%20Comparison%20of%20Three%20Surgical%20Techniques%20and%20Intra-Operative%20Shunt%20Use_AAM.pdf