TY  - JOUR
JF  - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
TI  - Retinal phenotyping of variants of Alzheimer's disease using ultra-widefield retinal images
SN  - 2352-8729
VL  - 13
IS  - 1
AV  - public
KW  - Alzheimer's disease
KW  -  drusen
KW  -  peripheral reticular pigmentary degeneration
KW  -  posterior cortical atrophy
KW  -  reticular pseudodrusen
KW  -  retinal imaging
KW  -  retinal phenotype
KW  -  sub?retinal deposit
KW  -  ultra?widefield imaging
ID  - discovery10135820
N2  - Background: Posterior cortical atrophy (PCA) is the most common atypical variant of Alzheimer's disease (AD). Changes associated with PCA in the brain affect the visual cortex, but little is known about retinal changes in PCA. In this study, we explored retinal phenotypic variations in typical AD (tAD) and PCA. Methods: Retinal phenotyping was carried out on ultra-widefield (UWF) images of 69 control, 24 tAD, and 25 PCA participants. Results: Individuals with tAD (odds ratio [OR] = 2.76 [confidence interval (CI):1.24 to 6.10], P = .012) and PCA (OR = 3.40 [CI:1.25 to 9.22], P = .016) were more likely phenotyped as hard drusen. tAD (OR = 0.34 [CI:0.12 to 0.92], P = .035) were less likely to have soft drusen compared to control. Almost 3-fold increase in reticular pseudodrusen formation in tAD (OR = 2.93 [CI:1.10 to 7.76], P = .030) compared to control was estimated. Discussion: Studying the peripheral retina may contribute to a better understanding of differences in retinal phenotypes of different AD variants.
UR  - https://doi.org/10.1002/dad2.12232
N1  - This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided
the original work is properly cited
Y1  - 2021///
A1  - Csincsik, L
A1  - Quinn, N
A1  - Yong, KXX
A1  - Crutch, SJ
A1  - Peto, T
A1  - Lengyel, I
ER  -