<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10135584> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/title> "Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/abstract> "Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. These may especially benefit the management of pancreatic ductal adenocarcinoma (PDAC), where therapy failure has been ascribed to its high cancer stem cell (CSC) content and high density of stromal cells and extracellular matrix (ECM). To date, these features are only partially reproduced ex vivo using organoid and sphere cultures. We have now developed a more comprehensive and highly tuneable ex vivo model of PDAC based on the 3D co-assembly of peptide amphiphiles (PAs) with custom ECM components (PA-ECM). These cultures maintain patient-specific transcriptional profiles and exhibit CSC functionality, including strong in vivo tumourigenicity. User-defined modification of the system enables control over niche-dependent phenotypes such as epithelial-to-mesenchymal transition and matrix deposition. Indeed, proteomic analysis of these cultures reveals improved matrisome recapitulation compared to organoids. Most importantly, patient-specific in vivo drug responses are better reproduced in self-assembled cultures than in other models. These findings support the use of tuneable self-assembling platforms in cancer research and pave the way for future precision medicine approaches."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/date> "2021-09-24" .
<https://discovery.ucl.ac.uk/id/document/1379045> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/volume> "12" .
<https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://xmlns.com/foaf/0.1/name> "Nature Communications"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20411723> .
<https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20411723> .
<https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://purl.org/ontology/bibo/issn> "20411723" .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-89760f3c310e040b66b2404d786b7ba6> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-89760f3c310e040b66b2404d786b7ba6> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-253e34d02a4e7ea69396566920d4e86c> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-253e34d02a4e7ea69396566920d4e86c> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-488a6fc2190cfbd72030c1b1312690cd> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-488a6fc2190cfbd72030c1b1312690cd> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d2c1f90c4168ab69138d1a652d8e09f0> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-d2c1f90c4168ab69138d1a652d8e09f0> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-48bca571fdd3f39a5a37d1eb37f33da4> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-48bca571fdd3f39a5a37d1eb37f33da4> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f40815ebc13081dff989e9361435bc07> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-f40815ebc13081dff989e9361435bc07> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b0d1731a34f8011758e8373246b8dcf9> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-b0d1731a34f8011758e8373246b8dcf9> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c0d72b4d37f19027bd027fc6a3829e37> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-c0d72b4d37f19027bd027fc6a3829e37> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fbde17c5206644728299c9756d2fa92a> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-fbde17c5206644728299c9756d2fa92a> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c2dc16c7f4d1eeb5293496c497792dca> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-c2dc16c7f4d1eeb5293496c497792dca> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fc12a2c04a9d6f988c7a165ce40c0895> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-fc12a2c04a9d6f988c7a165ce40c0895> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0cd37ccd898b220c0cb980842a3f1ec5> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-0cd37ccd898b220c0cb980842a3f1ec5> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-afe966b12d3b0f689f743d8e89acd642> .
<https://discovery.ucl.ac.uk/id/eprint/10135584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10135584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10135584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-afe966b12d3b0f689f743d8e89acd642> .
<https://discovery.ucl.ac.uk/id/person/ext-48bca571fdd3f39a5a37d1eb37f33da4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-48bca571fdd3f39a5a37d1eb37f33da4> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-48bca571fdd3f39a5a37d1eb37f33da4> <http://xmlns.com/foaf/0.1/familyName> "Sharma"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-48bca571fdd3f39a5a37d1eb37f33da4> <http://xmlns.com/foaf/0.1/name> "S Sharma"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dc16c7f4d1eeb5293496c497792dca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dc16c7f4d1eeb5293496c497792dca> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dc16c7f4d1eeb5293496c497792dca> <http://xmlns.com/foaf/0.1/familyName> "Scarpa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dc16c7f4d1eeb5293496c497792dca> <http://xmlns.com/foaf/0.1/name> "A Scarpa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2c1f90c4168ab69138d1a652d8e09f0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d2c1f90c4168ab69138d1a652d8e09f0> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2c1f90c4168ab69138d1a652d8e09f0> <http://xmlns.com/foaf/0.1/familyName> "Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2c1f90c4168ab69138d1a652d8e09f0> <http://xmlns.com/foaf/0.1/name> "Y Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0cd37ccd898b220c0cb980842a3f1ec5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0cd37ccd898b220c0cb980842a3f1ec5> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0cd37ccd898b220c0cb980842a3f1ec5> <http://xmlns.com/foaf/0.1/familyName> "Mata"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0cd37ccd898b220c0cb980842a3f1ec5> <http://xmlns.com/foaf/0.1/name> "A Mata"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f40815ebc13081dff989e9361435bc07> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f40815ebc13081dff989e9361435bc07> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f40815ebc13081dff989e9361435bc07> <http://xmlns.com/foaf/0.1/familyName> "Tatari"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f40815ebc13081dff989e9361435bc07> <http://xmlns.com/foaf/0.1/name> "M Tatari"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fc12a2c04a9d6f988c7a165ce40c0895> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fc12a2c04a9d6f988c7a165ce40c0895> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fc12a2c04a9d6f988c7a165ce40c0895> <http://xmlns.com/foaf/0.1/familyName> "Heeschen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fc12a2c04a9d6f988c7a165ce40c0895> <http://xmlns.com/foaf/0.1/name> "C Heeschen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-afe966b12d3b0f689f743d8e89acd642> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-afe966b12d3b0f689f743d8e89acd642> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-afe966b12d3b0f689f743d8e89acd642> <http://xmlns.com/foaf/0.1/familyName> "Loessner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-afe966b12d3b0f689f743d8e89acd642> <http://xmlns.com/foaf/0.1/name> "D Loessner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c0d72b4d37f19027bd027fc6a3829e37> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c0d72b4d37f19027bd027fc6a3829e37> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c0d72b4d37f19027bd027fc6a3829e37> <http://xmlns.com/foaf/0.1/familyName> "Erkan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c0d72b4d37f19027bd027fc6a3829e37> <http://xmlns.com/foaf/0.1/name> "M Erkan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fbde17c5206644728299c9756d2fa92a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fbde17c5206644728299c9756d2fa92a> <http://xmlns.com/foaf/0.1/givenName> "RT"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fbde17c5206644728299c9756d2fa92a> <http://xmlns.com/foaf/0.1/familyName> "Lawlor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fbde17c5206644728299c9756d2fa92a> <http://xmlns.com/foaf/0.1/name> "RT Lawlor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-89760f3c310e040b66b2404d786b7ba6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-89760f3c310e040b66b2404d786b7ba6> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-89760f3c310e040b66b2404d786b7ba6> <http://xmlns.com/foaf/0.1/familyName> "Osuna de la Peña"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-89760f3c310e040b66b2404d786b7ba6> <http://xmlns.com/foaf/0.1/name> "D Osuna de la Peña"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-253e34d02a4e7ea69396566920d4e86c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-253e34d02a4e7ea69396566920d4e86c> <http://xmlns.com/foaf/0.1/givenName> "SMD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-253e34d02a4e7ea69396566920d4e86c> <http://xmlns.com/foaf/0.1/familyName> "Trabulo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-253e34d02a4e7ea69396566920d4e86c> <http://xmlns.com/foaf/0.1/name> "SMD Trabulo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b0d1731a34f8011758e8373246b8dcf9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b0d1731a34f8011758e8373246b8dcf9> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b0d1731a34f8011758e8373246b8dcf9> <http://xmlns.com/foaf/0.1/familyName> "Behrens"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b0d1731a34f8011758e8373246b8dcf9> <http://xmlns.com/foaf/0.1/name> "D Behrens"^^<http://www.w3.org/2001/XMLSchema#string> .
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