eprintid: 10135448
rev_number: 26
eprint_status: archive
userid: 608
dir: disk0/10/13/54/48
datestamp: 2021-10-01 14:17:44
lastmod: 2022-09-07 06:10:28
status_changed: 2021-10-01 14:17:44
type: article
metadata_visibility: show
creators_name: Millman, LSM
creators_name: Hunter, ECM
creators_name: Orgs, G
creators_name: David, AS
creators_name: Terhune, DB
title: Symptom variability in depersonalization–derealization disorder: A latent profile analysis
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
keywords: anxiety, depersonalization-derealization disorder, dissociation, heterogeneity, latent profile analysis
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Objective: Depersonalization–derealization disorder (DDD) is characterized by diverse symptomatology overlapping with anxiety and dissociative disorders, but the sources of this variability are poorly understood. This study aims to determine whether symptom heterogeneity is attributable to the presence of latent subgroups. /

Method: We applied latent profile analysis to psychometric measures of anxiety, depersonalization–derealization, and dissociation in 303 DDD patients. /

Results: The analysis yielded evidence for five discrete subgroups: three of varying severity levels and two moderate-to-severe classes characterized by differential dissociative symptoms. The five classes reliably differed on several nondissociative symptoms, comorbidities, and factors precipitating their diagnosis but did not significantly differ in other symptoms including anxiety. /

Conclusion: These results suggest the presence of three distinct DDD subtypes in the upper severity range that are distinguished by differential expression of detachment and compartmentalization symptoms. Further elucidation of these subtypes has potential implications for the etiology, mechanisms, and treatment of DDD.
date: 2022-04
date_type: published
publisher: WILEY
official_url: https://doi.org/10.1002/jclp.23241
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1887513
doi: 10.1002/jclp.23241
lyricists_name: David, Anthony
lyricists_name: Hunter, Elaine
lyricists_id: ADDAV87
lyricists_id: EHHUN44
actors_name: Stacey, Thomas
actors_id: TSSTA20
actors_role: owner
full_text_status: public
publication: Journal of Clinical Psychology
volume: 78
number: 4
pagerange: 637-655
pages: 19
citation:        Millman, LSM;    Hunter, ECM;    Orgs, G;    David, AS;    Terhune, DB;      (2022)    Symptom variability in depersonalization–derealization disorder: A latent profile analysis.                   Journal of Clinical Psychology , 78  (4)   pp. 637-655.    10.1002/jclp.23241 <https://doi.org/10.1002/jclp.23241>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10135448/3/David_The%20prevalence%20of%20DDD_Final.pdf