eprintid: 10135448 rev_number: 26 eprint_status: archive userid: 608 dir: disk0/10/13/54/48 datestamp: 2021-10-01 14:17:44 lastmod: 2022-09-07 06:10:28 status_changed: 2021-10-01 14:17:44 type: article metadata_visibility: show creators_name: Millman, LSM creators_name: Hunter, ECM creators_name: Orgs, G creators_name: David, AS creators_name: Terhune, DB title: Symptom variability in depersonalization–derealization disorder: A latent profile analysis ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 keywords: anxiety, depersonalization-derealization disorder, dissociation, heterogeneity, latent profile analysis note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Objective: Depersonalization–derealization disorder (DDD) is characterized by diverse symptomatology overlapping with anxiety and dissociative disorders, but the sources of this variability are poorly understood. This study aims to determine whether symptom heterogeneity is attributable to the presence of latent subgroups. / Method: We applied latent profile analysis to psychometric measures of anxiety, depersonalization–derealization, and dissociation in 303 DDD patients. / Results: The analysis yielded evidence for five discrete subgroups: three of varying severity levels and two moderate-to-severe classes characterized by differential dissociative symptoms. The five classes reliably differed on several nondissociative symptoms, comorbidities, and factors precipitating their diagnosis but did not significantly differ in other symptoms including anxiety. / Conclusion: These results suggest the presence of three distinct DDD subtypes in the upper severity range that are distinguished by differential expression of detachment and compartmentalization symptoms. Further elucidation of these subtypes has potential implications for the etiology, mechanisms, and treatment of DDD. date: 2022-04 date_type: published publisher: WILEY official_url: https://doi.org/10.1002/jclp.23241 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1887513 doi: 10.1002/jclp.23241 lyricists_name: David, Anthony lyricists_name: Hunter, Elaine lyricists_id: ADDAV87 lyricists_id: EHHUN44 actors_name: Stacey, Thomas actors_id: TSSTA20 actors_role: owner full_text_status: public publication: Journal of Clinical Psychology volume: 78 number: 4 pagerange: 637-655 pages: 19 citation: Millman, LSM; Hunter, ECM; Orgs, G; David, AS; Terhune, DB; (2022) Symptom variability in depersonalization–derealization disorder: A latent profile analysis. Journal of Clinical Psychology , 78 (4) pp. 637-655. 10.1002/jclp.23241 <https://doi.org/10.1002/jclp.23241>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10135448/3/David_The%20prevalence%20of%20DDD_Final.pdf