TY  - JOUR
EP  - 655
KW  - anxiety
KW  -  depersonalization-derealization disorder
KW  -  dissociation
KW  -  heterogeneity
KW  -  latent profile analysis
A1  - Millman, LSM
A1  - Hunter, ECM
A1  - Orgs, G
A1  - David, AS
A1  - Terhune, DB
IS  - 4
TI  - Symptom variability in depersonalization?derealization disorder: A latent profile analysis
Y1  - 2022/04//
VL  - 78
SP  - 637
N2  - Objective: Depersonalization?derealization disorder (DDD) is characterized by diverse symptomatology overlapping with anxiety and dissociative disorders, but the sources of this variability are poorly understood. This study aims to determine whether symptom heterogeneity is attributable to the presence of latent subgroups. /

Method: We applied latent profile analysis to psychometric measures of anxiety, depersonalization?derealization, and dissociation in 303 DDD patients. /

Results: The analysis yielded evidence for five discrete subgroups: three of varying severity levels and two moderate-to-severe classes characterized by differential dissociative symptoms. The five classes reliably differed on several nondissociative symptoms, comorbidities, and factors precipitating their diagnosis but did not significantly differ in other symptoms including anxiety. /

Conclusion: These results suggest the presence of three distinct DDD subtypes in the upper severity range that are distinguished by differential expression of detachment and compartmentalization symptoms. Further elucidation of these subtypes has potential implications for the etiology, mechanisms, and treatment of DDD.
AV  - public
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
UR  - https://doi.org/10.1002/jclp.23241
ID  - discovery10135448
PB  - WILEY
JF  - Journal of Clinical Psychology
ER  -