TY - JOUR EP - 655 KW - anxiety KW - depersonalization-derealization disorder KW - dissociation KW - heterogeneity KW - latent profile analysis A1 - Millman, LSM A1 - Hunter, ECM A1 - Orgs, G A1 - David, AS A1 - Terhune, DB IS - 4 TI - Symptom variability in depersonalization?derealization disorder: A latent profile analysis Y1 - 2022/04// VL - 78 SP - 637 N2 - Objective: Depersonalization?derealization disorder (DDD) is characterized by diverse symptomatology overlapping with anxiety and dissociative disorders, but the sources of this variability are poorly understood. This study aims to determine whether symptom heterogeneity is attributable to the presence of latent subgroups. / Method: We applied latent profile analysis to psychometric measures of anxiety, depersonalization?derealization, and dissociation in 303 DDD patients. / Results: The analysis yielded evidence for five discrete subgroups: three of varying severity levels and two moderate-to-severe classes characterized by differential dissociative symptoms. The five classes reliably differed on several nondissociative symptoms, comorbidities, and factors precipitating their diagnosis but did not significantly differ in other symptoms including anxiety. / Conclusion: These results suggest the presence of three distinct DDD subtypes in the upper severity range that are distinguished by differential expression of detachment and compartmentalization symptoms. Further elucidation of these subtypes has potential implications for the etiology, mechanisms, and treatment of DDD. AV - public N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. UR - https://doi.org/10.1002/jclp.23241 ID - discovery10135448 PB - WILEY JF - Journal of Clinical Psychology ER -