TY - JOUR PB - OPTICAL SOC AMER N1 - Copyright © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement (https://doi.org/10.1364/OA_License_v1#VOR-OA). SP - 4401 Y1 - 2021/07// TI - Controlling the optical pathlength in continuous-wave reflectance spectroscopy using polarization EP - 4413 AV - public JF - Biomedical Optics Express N2 - We investigate potential improvements of continuous-wave diffuse reflectance spectroscopy within highly scattering media by employing polarization gating. Simulations are used to show the extent at which the effective optical pathlength varies in a typical scattering medium as a function of the optical wavelength, the total level of absorption, and the selected polarization channels, including elliptical and circular polarization channels. Experiments then demonstrate that a wavelength dependent polarization gating scheme may reduce the prior knowledge required to solve the problem of chromophore quantification. This is achieved by finding combinations of polarization channels which have similar effective optical pathlengths through the medium at each wavelength. UR - https://doi.org/10.1364/BOE.426627 VL - 12 A1 - Macdonald, CM A1 - Sridhar, S A1 - Do, HTX A1 - Luna-Labrador, J A1 - Adel, M A1 - Da Silva, A IS - 7 ID - discovery10134961 ER -