eprintid: 10134536 rev_number: 15 eprint_status: archive userid: 608 dir: disk0/10/13/45/36 datestamp: 2021-09-16 11:27:31 lastmod: 2021-09-17 22:27:30 status_changed: 2021-09-16 11:27:31 type: article metadata_visibility: show creators_name: Joshi, A creators_name: Vishnu G. K., A creators_name: Sakorikar, T creators_name: Kamal, AM creators_name: Vaidya, JS creators_name: Pandya, HJ title: Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects ispublished: inpress divisions: UCL divisions: B02 divisions: C10 divisions: D16 divisions: G88 keywords: Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Chemistry, Science & Technology - Other Topics, Materials Science, SURFACE-PLASMON RESONANCE, FREE ELECTROCHEMICAL DETECTION, DOPED SILICA NANOPARTICLES, LABEL-FREE DETECTION, SIGNAL AMPLIFICATION, GROWTH-FACTOR, ULTRASENSITIVE DETECTION, COLORIMETRIC DETECTION, QUANTUM DOTS, CARBON DOTS note: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. abstract: Timely and accurate diagnosis of breast cancer is essential for efficient treatment and the best possible survival rates. Biosensors have emerged as a smart diagnostic platform for the detection of biomarkers specific to the onset, recurrence, and therapeutic drug monitoring of breast cancer. There have been exciting recent developments, including significant improvements in the validation, sensitivity, specificity, and integration of sample processing steps to develop point-of-care (POC) integrated micro-total analysis systems for clinical settings. The present review highlights various biosensing modalities (electrical, optical, piezoelectric, mass, and acoustic sensing). It provides deep insights into their design principles, signal amplification strategies, and comparative performance analysis. Finally, this review emphasizes the status of existing integrated micro-total analysis systems (μ-TAS) for personalized breast cancer therapeutics and associated challenges and outlines the approach required to realize their successful translation into clinical settings. date: 2021-08-12 date_type: published publisher: ROYAL SOC CHEMISTRY official_url: https://doi.org/10.1039/D1NA00453K oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1887859 doi: 10.1039/d1na00453k lyricists_name: Vaidya, Jayant lyricists_id: JSVAI17 actors_name: Sharp, Catherine actors_id: CLSHA04 actors_role: owner full_text_status: public publication: Nanoscale Advances pages: 23 citation: Joshi, A; Vishnu G. K., A; Sakorikar, T; Kamal, AM; Vaidya, JS; Pandya, HJ; (2021) Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects. Nanoscale Advances 10.1039/d1na00453k <https://doi.org/10.1039/d1na00453k>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10134536/1/d1na00453k.pdf