<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10134493> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/title> "Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/abstract> "The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator of contact inhibition but the molecular mechanisms remain unclear. In this study we have used affinity proteomics to identify novel Merlin interacting proteins and show that Merlin forms a complex with multiple proteins involved in RNA processing including the PAFC and the CHD1 chromatin remodeller. Tumour-derived inactivating mutations in both Merlin and the CDC73 PAFC subunit mutually disrupt their interaction and growth suppression by Merlin requires CDC73. Merlin interacts with the PAFC in a cell density-dependent manner and we identify a role for FAT cadherins in regulating the Merlin-PAFC interaction. Our results suggest that in addition to its function within the Hippo pathway, Merlin is part of a tumour suppressor network regulated by cell-cell adhesion which coordinates post-initiation steps of the transcription cycle of genes mediating contact inhibition."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/date> "2021-08-23" . <https://discovery.ucl.ac.uk/id/document/1369941> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/volume> "16" . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/issue> "8" . <https://discovery.ucl.ac.uk/id/org/ext-75ea6aaed5eb22783511e404c3474352> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-75ea6aaed5eb22783511e404c3474352> <http://xmlns.com/foaf/0.1/name> "PUBLIC LIBRARY SCIENCE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-75ea6aaed5eb22783511e404c3474352> . <https://discovery.ucl.ac.uk/id/publication/ext-ceb82ca513fc49ffe2f82b12464bffce> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-ceb82ca513fc49ffe2f82b12464bffce> <http://xmlns.com/foaf/0.1/name> "PLoS One"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-ceb82ca513fc49ffe2f82b12464bffce> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10134493> 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<http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c3e619f0b62611e9e33f62eaaf1f4eb6> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-c3e619f0b62611e9e33f62eaaf1f4eb6> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c50933564d0fff98879d886d62244609> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-c50933564d0fff98879d886d62244609> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-42ed5ce66bc22256d94850112110c1bb> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-42ed5ce66bc22256d94850112110c1bb> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cf95ecb655f2925374245c71577892e2> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-cf95ecb655f2925374245c71577892e2> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-816cf5a56ef08b6761866784bb2a7a47> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-816cf5a56ef08b6761866784bb2a7a47> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-471880462f55aa4b53af65c26cc8c42e> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-471880462f55aa4b53af65c26cc8c42e> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-093df365830b825de524d5f3b21665a9> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-093df365830b825de524d5f3b21665a9> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1e1ba846002343c53d624df11baed576> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-1e1ba846002343c53d624df11baed576> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e281bb8b618b7bbcd8b79469b967e06d> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e281bb8b618b7bbcd8b79469b967e06d> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0b8078c33e9da3637f30632c7c7c86d7> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-0b8078c33e9da3637f30632c7c7c86d7> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6b7ed2b1ecd8cdcf879bd7c1be1260f8> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-6b7ed2b1ecd8cdcf879bd7c1be1260f8> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-65c3e736c4cbe78f23864c01422db136> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-65c3e736c4cbe78f23864c01422db136> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9b80b8deb68f41b298d078a1c3499c35> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-9b80b8deb68f41b298d078a1c3499c35> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9895e34ed631b583976fb2f2623fa4ff> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-9895e34ed631b583976fb2f2623fa4ff> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4fcc252edeaaa5c1434571f1c9618c23> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-4fcc252edeaaa5c1434571f1c9618c23> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-35c8ea3932199986fc79fd13437a0f8b> . <https://discovery.ucl.ac.uk/id/eprint/10134493> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> . <https://discovery.ucl.ac.uk/id/eprint/10134493#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-35c8ea3932199986fc79fd13437a0f8b> . <https://discovery.ucl.ac.uk/id/person/ext-42ed5ce66bc22256d94850112110c1bb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-42ed5ce66bc22256d94850112110c1bb> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-42ed5ce66bc22256d94850112110c1bb> <http://xmlns.com/foaf/0.1/familyName> "Henderson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-42ed5ce66bc22256d94850112110c1bb> <http://xmlns.com/foaf/0.1/name> "S Henderson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c50933564d0fff98879d886d62244609> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c50933564d0fff98879d886d62244609> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c50933564d0fff98879d886d62244609> <http://xmlns.com/foaf/0.1/familyName> "Chaib"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c50933564d0fff98879d886d62244609> <http://xmlns.com/foaf/0.1/name> "S Chaib"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-69c3361885086bce7feb0a2741560727> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-69c3361885086bce7feb0a2741560727> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-69c3361885086bce7feb0a2741560727> <http://xmlns.com/foaf/0.1/familyName> "Klupsch"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-69c3361885086bce7feb0a2741560727> <http://xmlns.com/foaf/0.1/name> "K Klupsch"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65c3e736c4cbe78f23864c01422db136> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-65c3e736c4cbe78f23864c01422db136> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65c3e736c4cbe78f23864c01422db136> <http://xmlns.com/foaf/0.1/familyName> "Munoz-Alegre"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65c3e736c4cbe78f23864c01422db136> <http://xmlns.com/foaf/0.1/name> "M Munoz-Alegre"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-093df365830b825de524d5f3b21665a9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-093df365830b825de524d5f3b21665a9> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-093df365830b825de524d5f3b21665a9> <http://xmlns.com/foaf/0.1/familyName> "Blees"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-093df365830b825de524d5f3b21665a9> <http://xmlns.com/foaf/0.1/name> "A Blees"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-107c90d24ce4e6c52dd332f0d7357d86> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-107c90d24ce4e6c52dd332f0d7357d86> <http://xmlns.com/foaf/0.1/givenName> "AE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-107c90d24ce4e6c52dd332f0d7357d86> <http://xmlns.com/foaf/0.1/familyName> "Roehrig"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-107c90d24ce4e6c52dd332f0d7357d86> <http://xmlns.com/foaf/0.1/name> "AE Roehrig"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cf95ecb655f2925374245c71577892e2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-cf95ecb655f2925374245c71577892e2> <http://xmlns.com/foaf/0.1/givenName> "W"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cf95ecb655f2925374245c71577892e2> <http://xmlns.com/foaf/0.1/familyName> "Emmett"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cf95ecb655f2925374245c71577892e2> <http://xmlns.com/foaf/0.1/name> "W Emmett"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e281bb8b618b7bbcd8b79469b967e06d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e281bb8b618b7bbcd8b79469b967e06d> <http://xmlns.com/foaf/0.1/givenName> 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